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SELECTBIO Conferences Innovations in API Manufacture 2022

Rodrigo de Souza's Biography

Rodrigo de Souza, Associate Professor, Federal University of Rio De Janeiro

Since I started my independent career I have pursued the development of new technologies in order to guide research by innovative ideas, which could be applied in industry. Over these years, I have published more then 160 articles, including reviews, original articles and perspectives, trying to establish our research line nationally and internationally. Our group has established continuous-flow technology for active pharmaceutical ingredients (API) synthesis in Brazil, showing that is possible to reduce costs on production allowing the reduction of the final price of the medicine. I have been recognized as CNPq fellow (Level 2) since I started at the University being also honored to receive for two consecutive times the Young Scientist Fellowship from the Rio de Janeiro Research State Foundation. A few years ago I received the Hanz Vietler prize for young scientist given by the Brazilian Chemical Society and also more recently the Innovation Prize in Industry, given by the Brazilian Association of Chemistry for a joint collaboration between our group and industry. Also, as a result from our international collaborations I was grated with the Alexander von Humboldt Fellowship for experienced researchers, which among other things, allowed 3 students from our group to take part of their research in one of the best laboratories in Germany.

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Process Intensification for API Synthesis: A New Window of Opportunity for Underdeveloped Countries

Thursday, 17 March 2022 at 16:45

Add to Calendar ▼2022-03-17 16:45:002022-03-17 17:45:00Europe/LondonProcess Intensification for API Synthesis: A New Window of Opportunity for Underdeveloped CountriesInnovations in API Manufacture 2022 in

Chemistry has over the decades been able to develop very complex transformations to produce multifunctional molecules. Despite these important advances, we are still using round bottom flasks and batch reactors to perform such transformations as 200 years ago. We are under a continuous-manufacturing transformation where technology will play a major role on the chemistry industry in the next years. The flow chemistry market reached $1.2 billion in 2018 and is expected to value $2.9 billions by the year of 2026, with a solid 11.3% CAGR. As the time flow synthesis can squeeze buildings for batch facilities under a portable container sized solution, the advantage using this type of production is becoming more and more evident. The inherent capacity of flow chemistry to reduce CAPEX and operational costs to a fraction, and to speed up processes and the suitability to take advantage on fully automated facilities, can lead flow chemistry towards a safer, cleaner and cheaper future than batch processing. Flow chemistry technology represents today, not only a bright future for chemical synthesis, but also represents an opportunity for underdeveloped countries to build their industrial bases and become self-sufficient regarding their needs for specialty chemicals, from basic pesticides for agriculture to complex molecules to support their basic health system, such as active pharmaceutical Ingredients (APIs). During the last years our group has focused efforts on the development of chemo and enzymatic methodologies towards the synthesis of fine chemicals, intermediates and final APIs, which are important for the chemical industry in Brazil. Several examples will be shown, some of them featuring cascade chemo-enzymatic reactions, on the synthesis of levetiracetam, ethambutol, crizotinib, donepezil, among others.

Add to Calendar ▼2022-03-17 00:00:002022-03-18 00:00:00Europe/LondonInnovations in API Manufacture 2022Innovations in API Manufacture 2022 in