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SELECTBIO Conferences Circulating Biomarkers: Cell-Free Nucleic Acids, Proteins and Rare Circulating Cells

Xandra Breakefield's Biography

Xandra Breakefield, Professor, Mass General Hospital (MGH)/Harvard Medical School

Xandra Breakefield, Ph.D. is a basic scientist with a strong background in molecular genetics and neuroscience. She focuses her research efforts on: gene therapy for neurologic diseases; and elucidation of the role of extracellular vesicles (EVs) released from cancer cells in tumor progression. She led early studies demonstrating mutant RNA in serum EVs from glioblastoma patients as biomarkers. She did her undergraduate work at Wilson College and her graduate work in Microbial Genetics at Georgetown University. She was a Postdoctoral Fellow with Nobel Prize winner, Dr. Marshall Nirenberg at the NIH. She is currently Professor of Neurology in the Neuroscience Program at Harvard Medical School and Geneticist in the Neurology and Radiology Services at Massachusetts General Hospital.

Professor Breakefield has received a number of awards for her work, including a McKnight Foundation Neuroscience Development Award, two Javits Neuroscience Investigator Awards, the Society for Neuroscience Mika Salpeter Lifetime Achievement Award, and the Harvard Medical School William Silen Lifetime Achievement Mentoring Award. She is a member of the National Academy of Arts and Sciences and past president of the American Society of Gene and Cell Therapy.

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EVs Add New Dimensions to Cancer Clinic

Monday, 20 March 2017 at 12:15

Add to Calendar ▼2017-03-20 12:15:002017-03-20 13:15:00Europe/LondonEVs Add New Dimensions to Cancer

Critical issues in cancer treatment are early detection, personalized data on gene drivers, and new therapies. In the case of both brain tumors, which are not easily accessible, and peripheral tumors, which may metastasize all over the body, we need to obtain clinically critical information from collective biofluids.  Extracellular vesicles (EVs) have become a clinically relevant resource of biomarker information by providing a means to sensitively detect mutant proteins, DNA and RNA in biofluids, including blood, cerebral spinal fluid (CSF) and urine samples.  Assays and devices to glean this information are emerging as products for clinical analyses. Waiting in the wings, and about to erupt, is the potential to use EVs as therapeutic delivery vehicles which can be derived from the patients’ own cells and target tumors throughout the body.

Add to Calendar ▼2017-03-20 00:00:002017-03-21 00:00:00Europe/LondonCirculating Biomarkers: Cell-Free Nucleic Acids, Proteins and Rare Circulating