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SELECTBIO Conferences Organ-on-a-Chip, Tissue-on-a-Chip Europe 2018

Noo Li Jeon's Biography

Noo Li Jeon, Professor, Seoul National University

Noo Li Jeon is a Professor of School of Mechanical and Aerospace Engineering at Seoul National University (SNU). He studied Materials Science and Engineering at Northwestern University (B.S.) and University of Illinois Urbana-Champagne (Ph.D.). He worked on soft lithography applications in Prof G.M. Whitesides’ laboratory at Harvard University and at Prof M. Toner’s group at Harvard Medical School. He was an Associate Professor at UC Irvine from 2001-2009 in the Department of Biomedical Engineering. In 2009, he moved to Seoul National University to join School of Mechanical Engineering at Seoul National University.

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Microfluidics within a Well: Injection-Molded Plastic Array for 3D Culture

Wednesday, 6 June 2018 at 14:30

Add to Calendar ▼2018-06-06 14:30:002018-06-06 15:30:00Europe/LondonMicrofluidics within a Well: Injection-Molded Plastic Array for 3D CultureOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The

Polydimethylsiloxane (PDMS) has been widely used in fabricating microfluidic devices for prototyping and proof-of-concept experiments. Due to several material limitations, PDMS has not been widely adopted for commercial applications that require large-scale production. This presentation will describe a mass-producible Injection-Molded Plastic Array for 3D Culture Tissue (IMPACT) platform that incorporates a novel microfluidic design to integrate patterned 3D cell culture within a single 96-well. Multiple hydrogel patterns can be sequentially assembled by utilizing capillary-guided flow along wedges and narrow gaps designed within the well. The patterning is quick and robust. It is as simple as placing a liquid droplet on any part of the wedge structure to obtain spontaneous patterning within 1 second. Optimal dimensionless parameters required for successful capillary loading have been determined. The IMPACT platform was used to co-culture HUVEC and LF, and to obtain angiogenic sprouts with lumens and tip cells that are comparable to those observed in PDMS based devices. This platform is expected to have a wide range of applications related to biological discovery, tissue engineering and drug screening, and can be used in a variety of scales from lab bench to automated equipment.

Add to Calendar ▼2018-06-05 00:00:002018-06-06 00:00:00Europe/LondonOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018Organ-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The