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SELECTBIO Conferences Screening Europe

Cedric Gaggioli's Biography

Cedric Gaggioli, Baby Team Leader, Université Nice Sophia Antipolis

Cedric Gaggioli completed his undergraduate studies at the Nice Sophia-Antipolis science university. In 2005 he graduated from the Nice science university, where he mainly focused on the role of the matrix proteins during melanomagenesis in Robert Ballotti’s lab. Cedric moved to London where he joined Erik Sahai’s lab, an expert in questions regarding cancer cell spreading and colonization of distant organs. Cedric showed that cancer cells can highjack carcinoma associated fibroblasts for local invasion through extracellular matrix remodeling and tracks formation. This original work led cedric to develop a 3D cell based assay to screen for compounds that could impair matrix remodeling. Since 2008, Cedric is back to France, in Nice. He is now established as an independent researcher, interested in the influence of the tumor microenvironment during carcinogenesis and more particularly in CAF-dependent signaling pathways that govern a pro-invasive matrix remodeling. Since 2012, Cedric is a young team leader focusing on the role of carcinoma-associated fibroblast in invasive cancer.

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3D Chemical Compounds Screening Assays to Uncover Cancer Cell Invasion Inhibitors

Wednesday, 18 February 2015 at 09:45

Add to Calendar ▼2015-02-18 09:45:002015-02-18 10:45:00Europe/London3D Chemical Compounds Screening Assays to Uncover Cancer Cell Invasion InhibitorsScreening Europe in Berlin, GermanyBerlin,

The collective invasion of carcinoma cells has been noted by pathologists for many years. It has been established that such specific type of tumor cells invasion require matrix metalloproteinase (MMP) activity, however, therapeutic strategies targeting MMP activity in patient have failed. Interestingly, Carcinoma Associated Fibroblasts (CAFs) can promote collective carcinoma cells invasion by extracellular matrix remodeling and tracks formation through actomyosin-dependent force generation. Using chemical compounds screening assay based on organotypic invasion assay and on 3D matrix remodeling by CAFs, we aim at identifying new compounds that could interfere with stroma cells during tumor cancer cell invasion and permissive microenvironment progression.

Add to Calendar ▼2015-02-17 00:00:002015-02-18 00:00:00Europe/LondonScreening EuropeScreening Europe in Berlin, GermanyBerlin,