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SELECTBIO Conferences Circulating Biomarkers, Exosomes & Liquid Biopsy Asia 2019

Chwee Teck Lim's Biography

Chwee Teck Lim, NUS Society Chair Professor, Department of Biomedical Engineering, Institute for Health Innovation & Technology (iHealthtech), Mechanobiology Institute, National University of Singapore

Professor Lim is NUS Society Chair Professor, Acting Director, Biomedical Institute for Global Health Research and Technology at the National University of Singapore. His research interests include the mechanobiology of human diseases and the development of microfluidic technologies for disease detection, diagnosis and therapy. He has authored more than 300 peer-reviewed papers (including 43 invited/review articles) and delivered more than 290 invited talks. He is an elected Fellow of the American Institute for Medical and Biological Engineering as well as an elected member of the World Council of Biomechanics. He currently sits on the editorial boards of 13 international journals. Prof Lim co-founded four startups which are commercializing technologies developed in his lab. He and his team have garnered more than 50 research awards and honors including the Asian Scientist 100 (2016), University’s Outstanding Researcher and Outstanding Innovator Awards (2014), the Credit Suisse Technopreneur of the Year Award, Wall Street Journal Asian Innovation Award (Gold) and the Asian Entrepreneurship Award (First Prize) (2012), President's Technology Award (2011) and the IES Prestigious Engineering Achievement Award (2010).

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Microfluidics Technologies for Cancer Diagnosis - From Cell Capture to Single Cell Analysis

Monday, 9 September 2019 at 11:15

Add to Calendar ▼2019-09-09 11:15:002019-09-09 12:15:00Europe/LondonMicrofluidics Technologies for Cancer Diagnosis - From Cell Capture to Single Cell AnalysisCirculating Biomarkers, Exosomes and Liquid Biopsy Asia 2019 in Seoul, KoreaSeoul,

The presence of Circulating Tumor Cells (CTCs) in bloodstream of patients is an important intermediate step in cancer metastasis and can provide valuable insights into disease detection and personalized treatment. As compared to obtaining a tissue biopsy which is invasive and painful, ‘‘liquid biopsy’’ for CTCs detection can be easily performed via a routine blood draw.  The presence and number of CTCs in peripheral blood has been associated with the severity of the disease and have potential uses for early detection, diagnosis, prognosis and treatment monitoring. However, the presence of the large number of blood cells complicates as well as makes detection of rare CTCs in blood of cancer patients extremely challenging. Here, we address these issues and demonstrate that physical biomarkers such as the unique size and deformability of CTCs can be effectively used for their detection and separation from blood via microfluidics.   We do this by leveraging on the many inherent advantages of microfluidics such as high sensitivity and spatial resolution, short processing time and low device cost. We developed a suite of microfluidic biochips that exploit the principles of cell size/deformability based separation as well as inertial focusing to perform high throughput continuous detection and separation of diseased cells.  These simple, efficient and cost effective microfluidic platforms will be invaluable in extracting viable CTCs for many downstream clinical applications including single cell analysis as well as personalized treatment.

Add to Calendar ▼2019-09-09 00:00:002019-09-10 00:00:00Europe/LondonCirculating Biomarkers, Exosomes and Liquid Biopsy Asia 2019Circulating Biomarkers, Exosomes and Liquid Biopsy Asia 2019 in Seoul, KoreaSeoul,