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SELECTBIO Conferences Flow Chemistry Summit 2022

Jesus Alcazar's Biography

Jesus Alcazar, Principal Chemist, Janssen Research & Development

Jesús Alcázar studied in Universidad de Castilla-La Mancha in Ciudad Real where he got his bachelor degree in 1990 and Ph. D. in 1996. As Ph. D. student he stayed for 6 months at the Royal Danish School of Pharmacy (Copenhagen, Denmark) under the direction of Prof. Michael Begtrup. In 1995 he joined Janssen-Cilag at the research center in Toledo. Currently he is Senior Principal Scientist at Janssen Research and Development. In this position he is involved in the implementation of novel technologies in Drug Discovery in Toledo and in collaboration with other J&J sites worldwide. In this role he has led the successful implementation of 3 different technologies: microwave, H-CUBE and Flow chemistry. From this work he has been author of around 50 articles, 4 reviews and 3 book chapters. In addition he has successfully applied these technologies to Medicinal Chemistry programs with 4 compounds selected as clinical candidates. This part of the work is reflected as inventor in more than 25 patent applications.

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Flow Chemistry in Drug Discovery: An Automated Tool to Introduce C(sp3) into Drug Molecules

Friday, 18 March 2022 at 11:30

Add to Calendar ▼2022-03-18 11:30:002022-03-18 12:30:00Europe/LondonFlow Chemistry in Drug Discovery: An Automated Tool to Introduce C(sp3) into Drug MoleculesFlow Chemistry Summit 2022 in Boston, USABoston,

Drug discovery process is currently under pressure to get bioactive molecules in the most efficient way. One approach that has been highlighted is the increasing fraction of the C(sp3) atoms in the final target compounds.  However, methodologies to introduce C(sp3) fraction into drug molecules are still challenging for medicinal chemistry and most high throughput chemistry in pharma relies on amide coupling, Suzuki reactions, reductive amination, nucleophilic substitution and sulfonylations. There is a clear need to develop new methodologies for such transformations that can be applicable in a Drug Discovery setting. Continuous flow chemistry has recently emerged as a novel chemical tool that can help synthetic chemists to access forbidden or forgotten chemistries and make them real alternatives for other more classical methods. In this way it enables access to novel chemical space not available by traditional batch procedures. In this presentation we are going to disclose how flow chemistry can be applied to discover new procedures for C(sp3) bond formation to increased Fsp3 in a Drug discovery.  These new methodologies can be transferred to automated platforms for the preparation of libraries and access this new chemical space in a high throughput format.

Add to Calendar ▼2022-03-17 00:00:002022-03-18 00:00:00Europe/LondonFlow Chemistry Summit 2022Flow Chemistry Summit 2022 in Boston, USABoston,