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SELECTBIO Conferences Organ-on-a-Chip, Tissue-on-a-Chip Europe 2018

Olivier Guenat's Biography

Olivier Guenat, Head, Organs-on-Chip Technologies, ARTORG Center for Biomedical Engineering Research, University of Bern-Switzerland

Olivier T. Guenat is the Head of the Organs-on-Chip Technologies Group at the ARTORG Center at the University of Bern in Switzerland. He is associated with the Pulmonary Medicine and the Thoracic Surgery Divisions of the University Hospital of Bern. His research focuses on the development of organs-on-chip, in particular lung-on-chips that mimic the healthy and diseased in-vivo cellular microenvironments of the lung. Prior to his position at the University of Bern, he held a position at the Swiss Center for Electronics and Microelectronics (CSEM), at the Ecole Polytechnique de Montréal (QC, Canada), before which he performed a post-doc at Harvard Medical School in Boston and at the University of Neuchâtel in Switzerland. He is the founder of AlveoliX, a biotech start-up that aims at bringing organs-on-chip on the market, for which he recently received the Ypsomed and the Venturekick Awards.

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Lung-on-Chip Models of the Healthy and Diseased Lung Parenchyma

Tuesday, 5 June 2018 at 16:30

Add to Calendar ▼2018-06-05 16:30:002018-06-05 17:30:00Europe/LondonLung-on-Chip Models of the Healthy and Diseased Lung ParenchymaOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The

The complexity of the lung can be illustrated by its delicate tree-like architecture that ends with the alveolar sacs, where the gas exchanges take place. This whole environment is subjected to a cyclic, mechanical constraint induced by the respiratory movements. We recently reported about an advanced in-vitro model of the lung parenchyma that mimics the key aspects of the lung alveolar environment in an unprecedented way (Stucki et al., Lab Chip, 2015). The system reproduces the three-dimensional mechanical strain induced by the respiratory movements, the air-liquid interface and the ultra-thin barrier, using an elastic membrane made of a 3um thin PDMS porous (3um pores) layer on which cells can be cultured on both sides. We could demonstrate that the physiological mechanical stress significantly affects a number of barrier functions, such as the transport of molecules though the barrier. Furthermore, in view to make the system widely accessible, great care was taken to make it robust and simple to use. In contrast to the lung-on-chip reported by the Wyss Institute in Boston (Huh et al. Science 2010), our device mimics the three-dimensional movements induced by the respiration (instead of a unidirectional stress in the Wyss lung-on-chip). We also demonstrated that the three-dimensional breathing motions of the alveolar barrier can be monitored in real time with a micro-impedance tomography system (Mermoud et al., Sensors and Actuators B: 2018). The development of the lung-on-chip was awarded with a number of prizes, including the Venturekick awards, a nomination at the Swiss Medtech Award in 2017 and is currently under development at AlveoliX, a start-up aimed at bringing organs-on-chip on the market. Recently, we reported about another part of the lung alveolar barrier, the lung microvasculature.  Lung endothelial cells and lung pericytes seeded in a micro-engineered environment filled with fibrin gel, self-assemble to build a network of perfusable and contractile microvessels of only a few tens of micrometers in diameter (Bichsel et al., Tissue Eng. A, 2015). We could demonstrate for the first time in-vitro that microvessels contract upon exposure to a vasoconstrictor. This model, made of primary human cells of the lung is of great relevance for the investigation of pathomechanism of lung diseases.

Add to Calendar ▼2018-06-05 00:00:002018-06-06 00:00:00Europe/LondonOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018Organ-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The