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SELECTBIO Conferences Circulating Biomarkers World Congress 2017

Dominique PV de Kleijn's Biography



Dominique PV de Kleijn, Professor Experimental Vascular Surgery, University Medical Center Utrecht, The Netherlands

Professor de Kleijn is since June 2012 Professor of Surgery at NUS/NUHS and preclinical director of the Cardiovascular Research Institute (CVRI). He is professor of Cardiovascular Immunology and co-chair of Experimental Cardiology at UMC Utrecht the Netherlands as well as professor of the Interuniversity Cardiology Institute of the Netherlands (ICIN). Since 1997 he is coordinating cardiovascular research from basal science, animal myocardial infarction studies (mouse and pig) towards clinical biobanking studies. Next to this, he is CTO of a UMC Utrecht spin-off biomarker company Cavadis BV and member of the Scientific Committee of ICIN and initiator and founder SOciety for Clinical Research and Translation of Extracellular Vesicles Singapore ”SOCRATES”. His research interests are: The innate immune system in cardiovascular disease and the response of the heart after infarction & Biomarkers predictive for primary & secondary events with a focus on plasma extracellular vesicles.

Dominique PV de Kleijn Image

Diagnosis of Ischemic Heart Disease Using Plasma Extracellular Vesicles

Monday, 20 March 2017 at 10:00

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Cardiovascular Disease (CVD) is with the cardiovascular events of Ischemic Heart Disease and Stroke, the number 1 and 2 cause of death in the world and expect to increase especially in Asia. Ischemic heart disease (IHD) comprises 3 entities: stable coronary artery disease (SCAD), unstable angina (UA) and myocardial infarction (MI). Because IHD is associated with an increased risk of adverse clinical events such as heart failure and death, early recognition of IHD is of utmost importance. However, to diagnosis IHD is challenging, as many patients present with atypical symptoms. It is known that women have a different symptom sensation than men. Troponins are the main diagnostic tool for detection of MI. Blood biomarkers for SCAD (typically causing stable angina) and UA, however, are not available. These diagnoses frequently require hospital visits/admissions for time-consuming and costly (non)invasive tests. We show that the plasma extracellular vesicle content can be used as an accurate source for early diagnosis of SCAD and UA.

Diagnosis of Ischemic Heart Disease Using Plasma Extracellular Vesicles

Monday, 20 March 2017 at 10:00

Add to Calendar ▼SELECTBIOenquiries@selectbiosciences.com

Cardiovascular Disease (CVD) is with the cardiovascular events of Ischemic Heart Disease and Stroke, the number 1 and 2 cause of death in the world and expect to increase especially in Asia. Ischemic heart disease (IHD) comprises 3 entities: stable coronary artery disease (SCAD), unstable angina (UA) and myocardial infarction (MI). Because IHD is associated with an increased risk of adverse clinical events such as heart failure and death, early recognition of IHD is of utmost importance. However, to diagnosis IHD is challenging, as many patients present with atypical symptoms. It is known that women have a different symptom sensation than men. Troponins are the main diagnostic tool for detection of MI. Blood biomarkers for SCAD (typically causing stable angina) and UA, however, are not available. These diagnoses frequently require hospital visits/admissions for time-consuming and costly (non)invasive tests. We show that the plasma extracellular vesicle content can be used as an accurate source for early diagnosis of SCAD and UA.


Add to Calendar ▼2017-03-20 00:00:002017-03-21 00:00:00Europe/LondonCirculating Biomarkers World Congress 2017Circulating Biomarkers World Congress 2017 in Boston, USABoston, USASELECTBIOenquiries@selectbiosciences.com