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SELECTBIO Conferences Microfluidics & Flow Chemistry Europe 2020

C. Oliver Kappe's Biography

C. Oliver Kappe, Professor and Scientific Director, Center for Continuous Flow Synthesis and Processing, University of Graz

C. Oliver Kappe is Professor of Chemistry at the University of Graz (Austria) and Scientific Director of the Center for Continuous Flow Synthesis and Processing (CC FLOW) at the Research Center Pharmaceutical Engineering GmbH (RCPE). He received his diploma (1989) and his doctoral (1992) degrees in organic chemistry from the University of Graz where he worked with Gert Kollenz on cycloaddition and rearrangement reactions of acylketenes. After periods of postdoctoral research work on reactive intermediates and matrix isolation spectroscopy with Curt Wentrup at the University of Queensland in Brisbane, Australia (1993-1994) and on synthetic methodology/alkaloid synthesis with Albert Padwa at Emory University in Atlanta, USA (1994-1996), he moved back to the University of Graz in 1996 to start his independent academic career. He obtained his „Habilitation“ in 1998 in organic chemistry and was appointed Associate Professor in 2000. Since 2011 he is Professor for „Technology of Organic Synthesis“ (Organische Synthesetechnologie) at the Institute of Chemistry at the University of Graz. He has spent time as visiting scientist/professor at e.g. the Scripps Research Institute (La Jolla, USA, K. Barry Sharpless, 2003), the Toyko Institute of Technology (Toyko, Japan, T. Takahashi, 2008), the Sanford-Burnham Institute for Medical Research (Orlando, USA, 2010) and the Federal University of Rio de Janeiro (Rio de Janeiro, Brazil, 2013-2015).

Professor Kappe has an extensive general experience and a 25 year track record in synthetic and physical organic chemistry, process intensification using batch microwave technology and flow chemistry/microreaction technology, communicated in ~400 scientific publications (Research ID, WoS h-Index 72). For the past decade the focus of his research has been directed towards flow chemistry/microreaction technology, encompassing a wide variety of synthetic transformations and experimental techniques. His research group is actively involved in projects dealing with API synthesis and manufacturing, employing a number of different enabling and process intensification technologies. For his innovative work in microwave chemistry he received the 2004 Prous Science Award from the European Federation for Medicinal Chemistry and the 2010 100.000 € Houska Prize in addition to a number of other awards. In 2015 he was named Fellow of the Royal Society of Chemistry.

C. Oliver Kappe is the Founding Editor and current Editor-in-Chief of the Journal of Flow Chemistry (Springer) and a board member of the Flow Chemistry Society. In addition he has been an Editor of the Journal QSAR and Combinatorial Sciences (Wiley-VCH, 2003-2007) and has served/serves on the Editorial/Advisory Boards of Green Chemistry, Reaction Chemistry & Engineering (RSC), Current Opinion in Green and Sustainable Chemistry (Elsevier), ChemMedChem and ChemSusChem (Wiley-VCH), Journal of Combinatorial Chemistry (ACS), Molecular Diversity (Springer), Journal of Heterocyclic Chemistry (Wiley-VCH) and a number of other journals. For several years he has been teaching courses on flow chemistry for Scientific Update.

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Applications of Flow Photochemistry Towards Industrial Scale Processing

Thursday, 10 September 2020 at 17:15

Add to Calendar ▼2020-09-10 17:15:002020-09-10 18:15:00Europe/LondonApplications of Flow Photochemistry Towards Industrial Scale ProcessingMicrofluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The

In recent years the popularization of synthetic photochemistry has brought with it a plethora of new methodologies, significantly enriching the chemist’s synthetic toolbox. Alongside classical UV-mediated photochemical methodologies, modern visible light methods (including photoredox transformations) are now being routinely included in synthetic routes at a small scale. These often offer unique disconnections, unachievable by alternative means, therefore, an efficient scale up strategy must be capable of including such transformations. As these molecules progress through stages of development, the process chemistry and manufacturing communities must be prepared, in terms of both equipment and expertise. Despite the inherent scalability implied by continuous flow processing, numerous obstacles are still present, including: reactor fouling, particularly when using UV irradiation; long reaction times, leading to low productivity; control of light flux over prolonged periods; and many more. With some extent of fundamental understanding around the reaction’s kinetic regime and irradiation requirements, the most suitable reactor and conditions can be chosen or developed. Accordingly, these obstacles can be overcome, or at least minimized, towards a robust and productive process. Herein, we present our experiences in developing a range of modern and classical photochemical transformations in continuous flow, in collaboration with industrial partners. These case studies will include: direct excitation and sensitized transformations, LED and arc lamp irradiation, tubing and plate-based reactors. The practical considerations, hurdles and solutions will be discussed, whilst maintaining a focus on application to processing on larger scales.

Add to Calendar ▼2020-09-10 00:00:002020-09-11 00:00:00Europe/LondonMicrofluidics and Flow Chemistry Europe 2020Microfluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The