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SELECTBIO Conferences BioEngineering 2017: BioMEMS, 3D-BioPrinting & Synthetic Biology

Keith Murphy's Biography

Keith Murphy, CEO, Organovo

Mr. Murphy has more than 20 years of experience in biotechnology, including serving in Product Strategy and Director of Process Development roles at Amgen. He is a co-founder of Organovo and has been responsible for all company operations since 2007. His ten years at Amgen included four years as Global Operations Leader for the largest development program in Amgen’s history, Phase 3 osteoporosis/bone cancer drug denosumab. At Amgen, he also worked to develop several other novel formulation and device products. Prior to Amgen, he played a central role at Alkermes, Inc. on the development team for their first approved product, Nutropin (hGH) Depot. He holds a B.S. in chemical engineering from the Massachusetts Institute of Technology and is an alumnus of the UCLA Anderson School of Management.

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3D-Bioprinted Human Liver Tissue For Chronic Liver Failure and Inborn Errors of Metabolism

Thursday, 16 March 2017 at 17:30

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Organovo has announced 3d bioprinted human liver tissue as the first transplantable tissue in its pipeline.  For patients in need of a liver transplant, no robust alternatives exist today.   Approximately 17,000 patients are on the U.S. liver transplant waiting list this year.  In addition, acute-on-chronic liver failure (“ACLF”), a recognized and distinct disease entity encompassing an acute deterioration of liver function in patients with liver disease, affects 150,000 patients annually in the United States.  Pediatric metabolic liver diseases represent another disease indication where a bioprinted liver tissue patch may show therapeutic benefits.  The combined total addressable market opportunity for treating these patients exceeds $3B. Organovo has performed preclinical studies in animal models showing engraftment, vascularization and sustained functionality of its bioprinted liver tissue, including stable detection of liver-specific proteins and metabolic enzymes.  With strong preclinical data in hand, Organovo is pursuing this compelling opportunity with a formal preclinical development program. Assuming development progresses according to its current expectations, Organovo intends to submit an Investigational New Drug (“IND”) application to the U.S. Food and Drug Administration (“FDA”) for its therapeutic liver tissue in three to five years.  As appropriate, Organovo will pursue breakthrough therapy designation, clinical development outside the United States, and other opportunities to accelerate time to market.

Add to Calendar ▼2017-03-16 00:00:002017-03-17 00:00:00Europe/LondonBioEngineering 2017: BioMEMS, 3D-BioPrinting and Synthetic BiologyBioEngineering 2017: BioMEMS, 3D-BioPrinting and Synthetic Biology in Boston, USABoston,