John Brennan,
Professor and Director, Biointerfaces Institute,
McMaster University
Professor John Brennan holds the Canada Research Chair in Bioanalytical Chemistry and Biointerfaces (Tier 1) and is Director of the Biointerfaces Institute at McMaster University. He is an expert in the development of biosensors and point-of-care diagnostics, with specific expertise in bioactive paper, high-throughput development of printable biomaterials, and development of solid-phase assays for diagnostics and small molecule screening. Dr. Brennan has published over 200 peer-reviewed papers, given over 150 invited presentations, and has been awarded several patents in the areas of POC diagnostics.
Biosensing Devices Integrating Functional Nucleic Acids for Detection of Bacterial and Viral Pathogens
Tuesday, 21 June 2022 at 16:00
Add to Calendar ▼2022-06-21 16:00:002022-06-21 17:00:00Europe/LondonBiosensing Devices Integrating Functional Nucleic Acids for Detection of Bacterial and Viral PathogensLab-on-a-Chip and Microfluidics Europe 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
DNA aptamers and DNA enzymes (denoted as functional nucleic acids or
FNA) are an emerging platform for development of point-of-care (POC)
diagnostic devices. In this presentation, I will first focus on the
development of new DNA aptamers and DNA enzymes for a range of key
biomarkers and their integration into colorimetric, fluorimetric and
electrochemical assays for detection of infectious diseases. Methods to
transduce the binding of a target to a FNA into the production of a DNA
strand as an output will then be described. The use the output DNA to
directly initiate color production, generate test lines on lateral flow
devices, or produce room temperature isothermal amplification through
rolling circle amplification methods will then be outlined. Finally,
the integration of the FNA assays into paper devices and electrochemical
sensors will be described as platform for a range of new POC devices
that allow facile detection of clinical analytes. Examples will be
provided outlining paper-based devices for ultra-sensitive detection of
bacteria such as Escherichia coli, Clostridium difficile, Helicobacter
pylori, Staphylococcus Aureus and SARS-CoV-2 will be described.
Add to Calendar ▼2022-06-21 00:00:002022-06-22 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics Europe 2022Lab-on-a-Chip and Microfluidics Europe 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2022-06-21 16:00:002022-06-21 17:00:00Europe/LondonBiosensing Devices Integrating Functional Nucleic Acids for Detection of Bacterial and Viral PathogensLab-on-a-Chip and Microfluidics Europe 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
