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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics Europe 2022

John Brennan's Biography



John Brennan, Professor and Director, Biointerfaces Institute, McMaster University

Professor John Brennan holds the Canada Research Chair in Bioanalytical Chemistry and Biointerfaces (Tier 1) and is Director of the Biointerfaces Institute at McMaster University. He is an expert in the development of biosensors and point-of-care diagnostics, with specific expertise in bioactive paper, high-throughput development of printable biomaterials, and development of solid-phase assays for diagnostics and small molecule screening. Dr. Brennan has published over 200 peer-reviewed papers, given over 150 invited presentations, and has been awarded several patents in the areas of POC diagnostics.

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Biosensing Devices Integrating Functional Nucleic Acids for Detection of Bacterial and Viral Pathogens

Tuesday, 21 June 2022 at 16:00

Add to Calendar ▼2022-06-21 16:00:002022-06-21 17:00:00Europe/LondonBiosensing Devices Integrating Functional Nucleic Acids for Detection of Bacterial and Viral PathogensLab-on-a-Chip and Microfluidics Europe 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

DNA aptamers and DNA enzymes (denoted as functional nucleic acids or FNA) are an emerging platform for development of point-of-care (POC) diagnostic devices.  In this presentation, I will first focus on the development of new DNA aptamers and DNA enzymes for a range of key biomarkers and their integration into colorimetric, fluorimetric and electrochemical assays for detection of infectious diseases.  Methods to transduce the binding of a target to a FNA into the production of a DNA strand as an output will then be described.  The use the output DNA to directly initiate color production, generate test lines on lateral flow devices, or produce room temperature isothermal amplification through rolling circle amplification methods will then be outlined.  Finally, the integration of the FNA assays into paper devices and electrochemical sensors will be described as platform for a range of new POC devices that allow facile detection of clinical analytes.  Examples will be provided outlining paper-based devices for ultra-sensitive detection of bacteria such as Escherichia coli, Clostridium difficile, Helicobacter pylori,  Staphylococcus Aureus and SARS-CoV-2 will be described.


Add to Calendar ▼2022-06-21 00:00:002022-06-22 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics Europe 2022Lab-on-a-Chip and Microfluidics Europe 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com