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SELECTBIO Conferences Innovations in API Manufacture 2022

Maurizio Benaglia's Biography

Maurizio Benaglia, Full Professor of Organic Chemistry, Dipartimento di Chimica, Università degli Studi di Milano

Maurizio Benaglia, since 2015 Full Professor of Organic Chemistry, at the Università degli Studi di Milano, is author of more than 230 publications on scientific international journals. His main research interests are the development of novel synthetic methodologies and their application to the synthesis of chiral pharmaceutical products, the design of new chiral organocatalysts, the study of visible light-driven reactions and organic electrosynthesis, to develop innovative and sustainable chemical processes, exploring the use of novel packed-bed and monolithic catalytic reactors, exploiting the unique features of such devices in stereoselective transformations in flow processes and studying organocatalyzed reactions in mini- and microreactors under continuous-flow conditions, taking advantage also of 3D-printing technologies. He was awarded by the Italian Chemical Society of the Ciamician medal (2001), and the Piero Pino Medal, he has been the director of the International School “Corbella” (2013-2017) and since 2017 he is the Director of the International School of Process Chemistry (ISPROCHEM). He is also Editor of the book “Catalyst Immobilization: Methods and Applications” (Wiley, 2020) and of the book “Organocatalysis -Stereoselective Reactions and Applications in Organic Synthesis” (DeGruyter, 2021), and Coordinator of national and international financed projects.

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Continuous Flow Technologies: A Powerful Tool for the Development of Sustainable, Stereoselective Catalytic Reactions

Thursday, 17 March 2022 at 10:30

Add to Calendar ▼2022-03-17 10:30:002022-03-17 11:30:00Europe/LondonContinuous Flow Technologies: A Powerful Tool for the Development of Sustainable, Stereoselective Catalytic ReactionsInnovations in API Manufacture 2022 in

The use of enabling technologies and continuous-flow systems are becoming more and more important in the synthesis of chiral APIs (active pharmaceutical ingredients). Organocatalytic reactions in (micro)-mesoreactors will be discussed, and compared with stereoselective catalytic in-flow reactions in 3D-printed reactors. The combination of organocatalysis and photochemistry can give access to molecules in one step which would otherwise be difficult to attain. Generally, the examples of asymmetric organocatalyzed photochemical reactions translated into continuous flow are rare. An efficient continuous flow photoredox reactor, that was incorporated as one unit of operation into the first fully telescoped, continuous asymmetric catalytic synthesis of a privileged API will be presented. A visible-light catalyzed cyclization of bis(enones) to afford enantiomerically enriched cyclopentane rings and a continuous flow approach to access alpha-trifluoromethylthiolated esters and amides starting from commercially available arylacetic acids will be also described.

Add to Calendar ▼2022-03-17 00:00:002022-03-18 00:00:00Europe/LondonInnovations in API Manufacture 2022Innovations in API Manufacture 2022 in