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SELECTBIO Conferences Bioengineering for Building Microphysiological Systems 2022

Femke de Vrij's Biography

Femke de Vrij, Associate Professor, Erasmus Medical Center

Femke de Vrij is Associate Professor at the department of Psychiatry at Erasmus MC Rotterdam. She is a neurobiologist with a main focus on cellular disease models to study the molecular and cellular mechanisms that underly psychiatric and neurodevelopmental disorders. She obtained her PhD at the Netherlands Institute for Neuroscience in Amsterdam studying the molecular mechanisms of Alzheimer's disease, continued by postdoctoral work at EMC on Fragile X Syndrome. She has been working with Steven Kushner in the department of Psychiatry since 2010, where she is now leading a research group applying induced pluripotent stem cell modeling of brain diseases.

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Human Adherent Cortical Brain Organoids in a Multiwell Format

Monday, 24 October 2022 at 14:30

Add to Calendar ▼2022-10-24 14:30:002022-10-24 15:30:00Europe/LondonHuman Adherent Cortical Brain Organoids in a Multiwell FormatBioengineering for Building Microphysiological Systems 2022 in Rotterdam, The NetherlandsRotterdam, The

Recent developments in induced pluripotent stem cell technology offer the unique opportunity to implement lineage-specific human cellular models suitable for drug development applications. Here, we expand on our platform for adherent cortical organoids that resemble the human frontal cortex during early development. The resulting 3D MICro-brains model the essence of cortical structure formation in a miniature format that is literally about 1-millionth the size of a normal human brain. The platform contains all relevant brain cell types: functional neurons and glial cell types in layered radial structures, including astrocytes, myelinating oligodendrocytes and microglia. This advanced 3D MICro-brain platform is amenable to high-throughput analyses for toxicity testing and screening purposes aimed at discovery of pathophysiological mechanisms and therapeutic compound testing for neurodevelopmental and psychiatric disorders.

Add to Calendar ▼2022-10-24 00:00:002022-10-25 00:00:00Europe/LondonBioengineering for Building Microphysiological Systems 2022Bioengineering for Building Microphysiological Systems 2022 in Rotterdam, The NetherlandsRotterdam, The