High Content Screening of an Antigen-Specific 3D Tumor-Spheroid/Primary T-cell Co-Culture System
Shane Horman,
Research Investigator,
Genomics Institute of the Novartis Research Foundation
Overcoming tumor-mediated immunosuppression and enhancing cytotoxic T-cell activity within the tumor microenvironment are two central goals of immuno-oncology (IO) drug discovery initiatives. Here we present a novel ultra-high-content assay platform for interrogating antigen-dependent T-cell-mediated killing of 3D tumor spheroids that yields multi-parametric, clinically-relevant data and can be employed kinetically for the discovery of novel IO therapeutic agents.
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