3D Printing of Full-Thickness Vascularized Human Skin Grafts
Pankaj Karande,
Associate Professor,
Rensselaer Polytechnic Institute
Dermal microvasculature not only promotes graft survival by supplying the tissue with oxygen and nutrients, but is also known to modulate inflammation and immune cell migration to the wound site. Vascularization of skin grafts is critical for successful skin engraftment. Here, using a 3D bioprinting platform, we show successful integration of a vascularized bed in a 3D printed full-thickness human skin model. We show the influence of different cell populations (fibroblasts, endothelial cells and pericytes) in controlling the formation of vasculature in vitro, and the successful integration of vascularized grafts in vivo.
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