A Universal Cancer Screening Test based on a Warburgian Extracellular Vesicle Biomarker
Winston Patrick Kuo,
President,
Predicine Holdings Ltd; Founder and Editor in Chief, Journal of Circulating Biomarkers
Cancer cells adopt a non-oxidative breakdown of glucose to produce energy, in contrast to healthy cells which mainly generate energy from oxidative breakdown of pyruvate. The underlying driver of tumorigenesis is an impaired cellular respiration caused by a dysfunction of mitochondria. It is has been demonstrated that cancer cells, and many cells grown in-vitro, exhibit glucose fermentation even when enough oxygen is present to properly respire, hence the phenomenon, the Warburg Effect. The presentation discusses the novelty and impact of a membrane protein targeting tumour metabolism along with cancer-specific biomarkers in both circulating and specific sub-populations of extracellular vesicles in most solid tumours (colon, gastric, breast, lung, prostate, ovarian and melanoma) for purposes of screening, diagnostics and monitoring therapeutic treatments.
|
|
