Circulating Tumor Cells Inform Mechanism of Breast Cancer Metastasis
Min Yu,
Assistant Professor,
University of Southern California
Circulating tumor cells (CTCs) are expected to contain
metastasis-initiating cells that can shed light on the mechanisms of
cancer metastasis. However, due to limited patient-derived material, the
metastatic capability of CTCs has yet to be proved. Using our recently
established patient-derived CTC lines, we found that different patient
CTC lines demonstrated distinct metastatic tissue tropisms in
immunodeficient mice and identified associated pathways to specific
organs via RNA-seq and ATAC-seq analysis.
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