Cellular Stress Sensor mTORC1 Switches Exosome Biogenesis and Secretion Pathways to Influence the Tumour Microenvironment
Deborah Goberdhan,
Professor,
University Of Oxford
I will discuss our data describing a new mechanism of exosome
biogenesis, conserved between humans and flies. We show that reduced
signalling from the cellular mTORC1 micro-environmental sensor, in
glutamine-depleted conditions, causes changes in membrane trafficking
and an upregulation of this alternate mechanism of exosome production.
This leads to the secretion of stress-induced exosomes, which induce
adaptive responses in recipient cancer cells.
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