Advanced Optofluidic Devices for Point-of-Care Molecular Diagnostics
Holger Schmidt,
Narinder Kapany Professor of Electrical Engineering,
University of California-Santa Cruz
Ultrasensitive and compact instruments with low complexity are highly desirable for real-time point-of-care disease detection. I will describe liquid-core waveguide optofluidic devices for both fluorescence and label-free detection of SARS-CoV-2 from clinical nasal swab samples with single molecule sensitivity. Multiplex detection of single viral antigens is demonstrated along with dual detection of viral DNA and antigen as well as label-free nanopore sensing of single RNAs with 2,000x enhanced detection rate. I will also discuss strategies for implementing optimized particle recognition algorithms and real-time analysis of weak fluorescence signals from single molecules.
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