A Platform for Detecting Tumor-Derived Exosomes
Lydia Sohn,
Professor, Department of Mechanical Engineering,
University of California, Berkeley
Late-stage lung-cancer diagnosis is the major contributor to the poor survival of lung cancer patients. The lack of symptoms specific to early-stage lung cancer and the low sensitivity and high cost of current screening methods, are current barriers to early diagnosis. To address this challenge and enable rapid, cost-effective lung cancer screening, we are developing a microfluidic platform to detect tumor-derived exosomes in saliva. Our detection method utilizes resistive-pulse sensing to measure the size change of a micron-sized antibody-coated colloid when tumor-derived exosomes bind to it. Microscale in size, our platform can easily be manufactured using standard lithographic techniques. In this talk, I will describe our platform and the results we have achieved thus far to demonstrate its utility toward detecting tumor-derived exosomes for earl-stage detection of lung cancer.
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