Integrated Optofluidic Platform for Single Bioparticle Analysis
Holger Schmidt,
Narinder Kapany Professor of Electrical Engineering,
University of California-Santa Cruz
We have developed an optofluidic platform that integrates biological sample preparation and optical single molecule analysis on a chip. I will describe the principle of the platform based on liquid-core optical waveguides and a broad range of capabilities that are enabled by this approach. These include the fluorescence analysis of single nucleic acids for amplification-free detection of Ebola infection as a new paradigm for molecular diagnostics with ultrahigh sensitivity and dynamic range. I will also describe multiplexed target detection with multi-mode interference waveguides for identification of single influenza viruses. The expansion of optofluidic capabilities through hybrid integration via nanopore-based electrical detection and integrated sample processing will be discussed.
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