Substrates for Generating Cancer Stem Cells and Highly Functional Hepatocytes
Mark Bradley,
Professor of Therapeutic Innovation, Precision Healthcare University Research Institute,
Queen Mary University of London
In my talk I will introduce polymer microarray technology; including our
inkjet mediated fabrication methodologies (which allows over 7000
different substrates to be made on a single glass slide) and describe
how this approach has been used in a large number of stem cell based
applications, notably:
(i). The use of polymer microarray
technology to discover a novel thermo-responsive chemically-defined
hydrogel for long term culture of human embryonic stem cells (Nature
Communication, 2013) and mesenchymal adipose derived stem cells
(Biomaterials, 2014)
(ii). Polymer discovery that were able to
support highly functional hESC-derived hepatocyte like cells (as active
as primary human hepatoctyes) (with David Hay see: Stem Cell Res, 2011
and WO2010106345)
(iii). The discovery and application of a substrate able to “lock-down” CSC’s in their CSC state
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