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“24” hours to pure sample from sample receipt
Mark Bayliss, Chief Scientific Officers, Virscidian Inc
Part of our drug discovery philosophy is to commence our lead evaluation with purified lead compounds that have been confirmed for presence and minimum acceptable purity prior to biological activity screening. The goal of a recent quality and performance improvement program was to reduce the time taken to analyze our lead compounds for target presence and purity, purify where necessary and then confirm the dried fraction(s) for target presence and final purity. On starting this improvement project our turnaround times were variable and typically required in excess of 3 – 4 days depending on the laboratory workload. Our goal was to be able to complete the entire turn-around time in 24 hours. Such a target required us to reevaluate our workflow in detail, increase levels of automation, increase quality of the automatically produced analytical results, decrease the time required for results review and reporting in each stage of the process.
Automated selection of optimal purification conditions from LC/MS and SFC/MS screening methods
Mark Bayliss, Chief Scientific Officers, Virscidian Inc
Screening methods are a high throughput common approach for accelerating method development for chromatographic separations. Using this approach, several method conditions can be screened in serial or parallel to reduce or eliminate timely method development. However, as the numbers of method conditions are increased, inevitably the amount of time to review and select the optimal condition increases. An automated flexible and dynamic method selection package was implemented to analyze and review both SFC and HPLC screening conditions.
Enhancing the Laboratory Automation Process. AeQuus for automated monitoring of fluid levels of analytical instruments.
Dawn Browning, Conference Organiser, TTP Labtech Ltd
Laboratory automation in the pharmaceutical industry has been expanding rapidly over the past decade, providing higher productivity, precision and quality. By reducing the number of manual repetitive tasks and potential error, there are also significant time savings which allows the scientist to concentrate on research not routine. Many companies have made huge investments in automated systems, ranging from liquid handling for tube and plate setup during compound and biological screening, automation of analytical equipment and high content screening assays for analysis of biological interactions. Despite extensive automation, the process of equipment maintenance still relies on manual input. Analytical instruments such as HPLC, Mass Spec etc require constant manual monitoring of supply and waste vessels and the introduction of AeQuus by TTP LabTech, an automated non-contact sensor for the monitoring of system fluids provides a simple solution to enhance the laboratory automation process.
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