Shopping Cart (0)
My Account

Shopping Cart
SELECTBIO Conferences Circulating Biomarkers World Congress 2020

Circulating Biomarkers World Congress 2020 Agenda


Print Agenda

Monday, 17 February 2020

00:00

Michael GranerConference Chair

Title to be Confirmed.
Michael Graner, Associate Professor, Dept of Neurosurgery, University of Colorado Anschutz School of Medicine, United States of America

00:00

Steve SoperKeynote Presentation

Title to be Confirmed.
Steve Soper, Foundation Distinguished Professor, Director, Center of BioModular Multi-scale System for Precision Medicine, The University of Kansas, Adjunct Professor, Ulsan National Institute of Science & Technology, United States of America

00:00

Title to be Confirmed.
Kendall Van Keuren-Jensen, Associate Professor, Translational Genomics Research Institute, United States of America

00:00

Dominique PV de KleijnKeynote Presentation

Title to be Confirmed.
Dominique PV de Kleijn, Professor Experimental Vascular Surgery, Professor Netherlands Heart Institute, University Medical Center Utrecht, The Netherlands, Netherlands

00:00

Michael HellerKeynote Presentation

Title to be Confirmed.
Michael Heller, Distinguished Scientist - Knight Cancer Institute at Oregon Health & Science University (OHSU), Center for Cancer Early Detection and Research (CEDAR); Professor, University of California-San Diego, United States of America

00:00

Daniel ChiuKeynote Presentation

Title to be Confirmed.
Daniel Chiu, A. Bruce Montgomery Professor of Chemistry, University of Washington, United States of America

00:00

Mehmet TonerKeynote Presentation

Title to be Confirmed.
Mehmet Toner, Helen Andrus Benedict Professor of Biomedical Engineering, Massachusetts General Hospital (MGH), Harvard Medical School, and Harvard-MIT Division of Health Sciences and Technology, United States of America

00:00

Title to be Confirmed.
Shivani Sharma, Associate Director, California NanoSystems Institute, California NanoSystems Institute, UCLA, United States of America

00:00

Title to be Confirmed.
Taylor Jensen, Director, Research and Development, Sequenom (a LabCorp Company), United States of America

00:00

Utkan DemirciKeynote Presentation

Title to be Confirmed.
Utkan Demirci, Professor, Stanford University School of Medicine, United States of America

00:00

Lydia SohnKeynote Presentation

Title to be Confirmed.
Lydia Sohn, Professor of Mechanical Engineering, University of California-Berkeley, United States of America

00:00

Applying Phage-Displayed Random Peptide Libraries to Identify Exosomes as Biomarkers in Patients with Central Nervous System Disorders
Xiaoli Yu, Assistant Professor, University of Colorado Anschutz Medical Campus, United States of America

Like most other cells, brain tumor cells shed extracellular vesicles (EV) into their external environment and are considered potentially high-value biomarker reservoirs. We hypothesize that phage-displayed random peptide libraries can be applied to identify EV of CNS origin, and high affinity phage peptides can be used for rapid isolation and characterization of extracellular vesicles from blood of patients with brain tumors. Phage display has been successfully applied to many different areas of research, including immunology, cancer, drug discovery, epitope mapping, protein-protein interactions, and infectious diseases, targeting a broad cross section of protein families. Phage display technology is based on the construction of a polypeptide library fused to a bacteriophage coat protein. Phage are screened (“panned”) on surfaces coated with potential targets. We have applied two Phage-display peptide libraries (7mer &12 mer) and identified high affinity peptides specific to exosomes derived from brain tumor cell-lines and plasma of patients with other CNS disorders. The peptides shared high sequence homologies within the ones selected by the same panning targets as well as with others panned by exosomes from different sources. Our data suggest that phage peptide technologies can be used for enrichment, isolation, and characterization of EVs derived from different CNS cell types from blood of brain tumor patients and other CNS disorders.

00:00

Min YuKeynote Presentation

Circulating Tumor Cells Inform Mechanism of Breast Cancer Metastasis
Min Yu, Assistant Professor, University of Southern California, United States of America

Circulating tumor cells (CTCs) are expected to contain metastasis-initiating cells that can shed light on the mechanisms of cancer metastasis. However, due to limited patient-derived material, the metastatic capability of CTCs has yet to be proved. Using our recently established patient-derived CTC lines, we found that different patient CTC lines demonstrated distinct metastatic tissue tropisms in immunodeficient mice and identified associated pathways to specific organs via RNA-seq and ATAC-seq analysis.

00:00

John NolanKeynote Presentation

Title to be Confirmed.
John Nolan, Professor, The Scintillon Institute, United States of America

00:00

Linking Pain-Regulated Exosomal-miRNAs to Target Expression in the Brain
Natasha Sosanya, Staff Scientist, USAISR, United States of America

Nerve injury in male rat’s results in differential expression (DE) of circulating exosomal-miRNAs (ex-miRNAs). The DE ex-miRNAs affect target expression and signaling pathways that contribute to the development of neuropathic pain.

00:00

Capturing Heterogeneous Circulating Tumor Cells in Breast and Lung Cancer Using Nanotube-CTC-Chip
Balaji Panchapakesan, Professor, Department of Mechanical Engineering, Worcester Polytechnic Institute (WPI), United States of America

The ability to detect cancer and its heterogeneity non-invasively in the earliest of stages can make a significant clinical impact. Therefore, biopsy of blood and other bodily fluids also called “liquid biopsy” is an emerging concept for non-invasive detection and capture of circulating tumor cells. Circulating biomarkers is a rapidly growing field of research. Circulating biomarkers include, circulating tumor cells (CTCs), exosomes, circulating tumor DNA (ctDNA), cell-free DNA and RNA (mRNA, miRNA, non-coding RNA, and other RNAs), circulating proteins and metabolites. However, the clinical impacts of liquid biopsy are yet to be realized. We describe the nanotube-CTC-chip for capture and analysis of heterogeneous circulating tumor cells. Using a micro-array technology, well established in the clinical domain, and utilizing nanosurfaces, we demonstrate the capture and isolation of invasive CTCs and CTCs of multiple phenotypes in breast and lung cancer patients.


Agenda is not currently available
Add to Calendar ▼2020-02-17 00:00:002020-02-18 00:00:00Europe/LondonCirculating Biomarkers World Congress 2020Circulating Biomarkers World Congress 2020 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com