Nanomedicine 2013 Agenda

Registration

Coffee and Networking in Exhibiton Hall

Lunch and Networking in Exhibition Hall

Poster Viewing Session

On the Impact of Surface Hydrophobicity on the Toxicity of Inhaled Soft, Organic Nanomaterial
Marie-Christine Jones, Lecturer, University of Birmingham, United Kingdom

This presentation will explore the role of surface hydrophobicity as a driving force behind the toxicity of inhaled organic nanomaterials. Specifically, this study aimed to verify the premise that adverse reactions in the lung can be reduced through a decrease in surface hydrophobicity.

Silver Nanocomposites for Biomedical Applications
Meenal Kowshick, Assistant Professor, Birla Institute of Technology & Science Pilani, India

Silver is a powerful antimicrobial and anti-inflammmatory agent that exhibits strong cytotoxicity towards an array of microorganisms and a remarkably low human toxicity. With the rapid emergence of multi-drug resistant microorganisms, the use of silver based antimicrobials is re-emerging as an effective non-resistance-inducing strategy to prevent recurrence of infections. Our work on biomedical applications of silver composites with chitin, hydroxyapatite, titanium dioxide, etc will be presented.

Coffee and Networking in Exhibiton Hall

Tumour Regression After Intravenous Administration of Novel Tumour-targeted Nanomedicines
Christine Dufes, Senior Lecturer, University of Strathclyde, United Kingdom

The possibility of using genes as medicines to treat cancer is limited by the lack of efficacious delivery systems able to selectively deliver genes to tumours. We demonstrated that the intravenous administration of a tumour-targeted dendriplex led to tumour disappearance of 90% of the tested tumours over one month.

Nanoparticle Formation Using Advanced Focused Acoustics
Carl Beckett, General Manager, Covaris Process Technologies, United States of America

In this presentation we will discuss the use of Focused Acoustics for the processing of key nanoparticle delivery systems, including liposomes, emulsions, and nanosuspensions.  Key limitations of current methods will be addressed, including temperature and solvent sensitive APIs, scalability, and sterile, continuous flow manufacturing capabilities.  Example data is provided to show that the method or process by which a Formulation is formed, has a direct impact on the effectiveness of the Formulation.  Both small molecule and biological Formulations will be discussed.

CANCELLED - Amphoteric Polyamidoamines of Nanomedical Interest
Paolo Ferruti, Professor, Universita di Milano, Italy

Poly(amidoamine)s (PAAs) are biodegradable tert-amine polymers obtained by polyaddition of amines to bisacrylamides. Recently, it has been found that some highly biocompatible amphoteric PAAs are endowed with strong antiviral activity and, in addition, give non-covalent adducts with primaquine and chloroquine whose antimalarial activity is dramatically higher than that of the free drugs.

End of Day One

The Janus Face of Nanotechnology
Seamus Higson, Professor/Head, Cranfield University, United Kingdom

Nanotechnology is a dramatically expanding new area of science. Nano-materials are often customised for a particular application. This diversity of form and chemical nature poses problems in terms of risk assessment.  This talk will aim to explain our current scientific understanding about the potential harmful effects of these ubiquitous materials.

Coffee and Networking in Exhibiton Hall

Cell Mediated Nanoencapsulated (CMN) Drug Delivery into Deep Lungs
Arun Kumar, Assistant Professor, University of Delaware, United States of America

To overcome drug delivery limitations we developed a SNAP (Sertoli cells nanoparticle mediated protocol). In this protocol we isolated rat Sertoli cells and preloaded with chitosan nanoparticles and used to obtain a high-density distribution and concentration (~ 90%) of the drug nanoparticles in the deep lungs of mice. This delivery protocol can be optimized for drug therapy of most complicated disease of the lungs.

Cationic Nanoparticles for Cancer Chemotherapy
Erem Bilensoy, Associate Professor, Hacettepe University, Turkey

Nanoparticles are promising delivery systems for the local or systemic application of anticancer drugs and active molecules with bioavailability problems. As a result of their favourable size distribution, nanoparticles can be targeted to tumor tissues via the Enhanced Permeation and Retention (EPR) Effect. In this sense, active targeting of anticancer drugs may also be achieved by surface modification of the nanoparticles. Positive surface charge affects the intracellular drug delivery and cellular uptake of nanoparticles due to improved interaction with biological membranes.  Potential of cationic nanoparticles will be discussed in view of in vitro, cell culture and in vivo data.

Lunch and Networking in Exhibition Hall

Poster Viewing Session

Coffee and Networking in Exhibiton Hall

Polymeric Nanoparticles for Oral Chemotherapy
Maite Agueros Bazo, Postdoc Researcher, University of Navarra, Spain

The presentation will try to show the abilities of poly(anhydride) nanoparticles to improve the oral bioavailability of anticancer drugs with poor permeability properties due to a presystemic metabolism (i.e paclitaxel). The resulting nanoparticles may be of interest to develop oral metronomic therapies.

CANCELLED - Micelle-encapsulated Thiostrepton is an Effective Nanomedicine for Inhibiting Tumor Growth
Andrei Gartel, Associate Professor, University of Illinois at Chicago, United States of America

We explored the potential in vivo anticancer properties of thiostrepton, delivered through nanoparticle encapsulation to xenograft models of breast and liver cancer. Maximum accumulation of micelle-thiostrepton nanoparticles (100nm in diameter, -16mV in zetapotential) into tumors was retained for at least 24 hours and reduced tumor growth of human cancer xenografts.

Close of Conference