Lab-on-a-Chip European Congress Agenda

Registration

From Microfluidic Components to a true Lab-on-a-Chip - Modular Approaches for Integrated Microfluidics
Holger Becker, Chief Scientific Officer, Microfluidic ChipShop GmbH, Germany

We have developed a strategy using modularized microfluidic devices as well as hardware modules in order to speed up the development of highly integrated microfluidics-enabled products for diagnostics and the life sciences.

Coffee & Networking in Exhibition Hall

Single Cell Analysis on Acute Myleloid Leukemia Patient Cell Samples: Microfluidic Data Collection and Clinical Implications
Paul Li, Professor, Simon Fraser University, Canada

Multidrug resistance (MDR) is the major cause of failure in chemotherapy of acute myeloid leukemia (AML). The reversal effects of MDR inhibitors are investigated to improve chemotherapy sensitivity using a microfluidic method for single-cell measurements.

Monitoring Dynamic Interactions of Tumor Cells with Tissue and Immune Cells in a Lab-on-a-Chip
Peter Ertl, Senior Scientist, Austrian Institute Of Technology, Austria

We have developed, characterized and evaluated a complementary cell analysis method to assess the dynamic interactions of tumor cells with resident tissue and immune cells using optical light scattering and impedance spectroscopy to shed light on tumor cell behavior.

Technology Spotlight:
Microfluidic Market Update
Frederic Breussin, Business Unit Manager, Yole Developpement

Lunch & Networking in Exhibition Hall

Poster Viewing Session

Free Workshop
Takara Clontech Lunchtime Workshop - Improved cDNA Library Generation for Transcriptome Analysis from a Single Cell
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Labs, Cells and Organs on a Chip
Albert Van Den Berg, Professor, University Of Twente, Netherlands

Different Labs on a Chip for healthcare applications will be presented, followed by some examples of cells on chip and finally the possibility to realize organs on chip for drug development applications.

Micro-processing Tools for Cells and Worms
Xavier Casadevall i Solvas, Senior Scientist, Imperial College London, United Kingdom

Micro-engineered platforms present new opportunities for biological experimentation at the single organism level. In this talk I will introduce novel strategies for the manipulation and the study of C. elegans nematodes and single cells.

Coffee & Networking in Exhibition Hall

Novel Strategies in Single Molecule Sensing using Multiphase Microfluidics
Joshua Edel, Professor, Imperial College London, United Kingdom

This talk highlights novel strategies for the detection of single molecules using multiphase microfluidics.

Automated Droplet Microfluidics for Studies of Emergence of Drug Resistance in Bacteria
Piotr Garstecki, Associate Professor, Polish Academy Of Sciences, Poland

We describe microfluidic technology for parallel cultivation of hundreds of colonies of bacteria in microdroplets, each individually addressed for its chemical environment and continuously monitored. The platform allows for highly parallel, long-term studies of microbial ecology, physiology and evolution. 

Technology Spotlight:
Nanoscale Spotting: Picoliter Droplet Dispensing to Enable High-throughput Experimentation
Claude Dufresne, Business Development Director, Scienion

The need to successfully deposit very small volumes of biological and chemical content on devices exists across a wide range of applications, in research and diagnostics, such as microarray spotting on glass surfaces, and depositing samples on pre-defined microfluidics targets. Our non-contact dispensing technology has been perfected to reliably deliver droplets in the 70 to 800 picoliter range. It has been implemented in a way that allows for a very smooth transition from basic R&D activities all the way to full manufacturing-scale utilization. The presentation will illustrate how this is implemented in a wide range of applications.

Roundtable Discussion
Frederic Breussin, Business Unit Manager, Yole Developpement, France

Market Acceptance of Microfluidic Technologies: A Road Towards Standardization

Multiplexed Infectious Disease Testing - Sound Point-of-Care Diagnostics
Jon Cooper, Professor, University of Glasgow, United Kingdom

We have developed a new technology which enables us to shape acoustic fields and tailor their interaction with fluids. We have now demonstrated the concept on a range of medical diagnostics, from in vivo glucose sensing to molecular assays, enabling sample preparation, reagent actuation and sensing. We currently have a range of projects exploring multiplexed clinical testing for malaria, tuberculosis and sexually transmitted diseases, with NHS partners.

Coffee & Networking in Exhibition Hall

LabTube – A Novel "Microfluidic App" for Sample Preparation and Diagnostics Operated in a Laboratory Centrifuge
Felix Von Stetten, Head, HSG IMIT, Germany

The LabTube is a novel lab-on-a-chip cartridge processed by a laboratory centrifuge. Not requiring specialized processing devices this "microfluidic app" has low market entry barriers. Fully automated DNA-extraction and protein purification are demonstrated. The LabTube is amenable to sample-to-answer diagnostics.

Lab-on-DVD: A Novel Platform for Point of Care Diagnostics
Aman Russom, Associate Professor, Royal Institute of Technology, Sweden

We report on a “Lab-on-DVD” concept, where a commercial DVD drive is turned into an improved DVD-based Laser Scanning Microscope (DVD- LSM) with demonstrated sub-micrometer image resolution for POC diagnostics.

Technology Spotlight:
Next Generation Sequencing: New Opportunities for Lab on Chip
Benjamin Roussel, Business Unit Manager of the Microfluidic & Medical Technologies (MedTech), Yole Développement

Lunch & Networking in Exhibition Hall

Poster Viewing Session

Extruded Microfluidics for Simple-Multiplex Molecular Diagnostics
Nuno Reis, Lecturer, Loughborough University, United Kingdom

We have implemented a new generation of extruded microfluidic devices for rapid molecular diagnostics.

Novel Functions in Bio- and Fluidic Microstructures Using the Off-Stoichiometry Thiol-Ene (OSTE) Polymer Platform
Wouter van der Wijngaart, Professor, KTH Royal Institute of Technology, Sweden

We have formulated and demonstrated a novel, superior, polymer system, OSTE, and its manufacturing platform, which is based on the mixture of three monomers: thiols, -enes and epoxies. The uniqueness of the OSTE approach stems from the curing in two distinct steps: after the first cure, an intermediate polymer is formed which is ideally suited for surface modifications and bonding; after the second cure we obtain an inert and robust polymer. The talk will introduce the novel polymer, and show functional medical and microfluidic components that demonstrate the unique opportunities that OSTE provides in terms of mechanical properties, surface modification and bonding.

Coffee & Networking in Exhibition Hall

Microfluidic Systems for Biomarker Analysis and Cancer Diagnosis
Martin Gijs, Professor, Ecole Polytechnique Federale de Lausanne, Switzerland

We describe microfluidic systems for (i) implementation of a sensitive immunoassay by using manipulation of magnetic microparticles and (ii) for accurate assessment of immunohistochemical biomarker expression on cancer tissue slices.

Lab-on-Chip Systems for Pathogen Analysis
Gerald Urban, Professor, Albert Ludwigs Universität Freiburg, Germany

Microfluidic and nanotechnological systems on chip exhibit the potential of cell based analysis especially pathogen detection on chip. Their use and suitability to be integrated into highly-sensitive bioanalytical tests was demonstrated so far. Unsolved problems are the detection of low concentrations of pathogens in real environment samples without any interference. The integration of actuation elements, electrophoresis, enrichment and purification steps enable the rapid detection of pathogen in real samples.

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