Abstract

3D Bioprinting of Living Tissues and Organs: From Basic Science to Clinical Translation

Ibrahim Ozbolat, Hartz Family Associate Professor of Engineering Science and Mechanics, Huck Institutes of the Life Sciences at Penn State University

3D Bioprinting is a disruptive technology enabling deposition and patterning of living cells in order to manufacture replacement tissues and organs for tissue engineering, regenerative medicine, disease modeling and drug screening purposes. In this talk, Dr. Ozbolat will survey the emerging field of bioprinting and its impact on medical sciences. In the first part of his seminar, he will present a wide range of 3D bioprinting efforts in manufacturing of tissue/organ substitutes performed in his laboratory in the last nine years. In the second part, he will present a new bioprinting technique, called aspiration-assisted bioprinting, and explain the underlying physical mechanism in order to understand the interactions between physical governing forces and aspirated viscoelastic tissue building blocks. Finally, he will demonstrate a new intraoperative bioprinting approach in order to repair composite soft/hard tissues during craniofacial reconstruction on a rat model in a surgical setting.