Abstract

Nuclear Transport of Extracellular Vesicles

Aurelio Lorico, Professor of Pathology, Touro University Nevada School of Medicine

We have recently identified a novel nuclear path, where Rab7+ late endosomes enter into nuclear envelope invaginations and mediate the nuclear translocation of EV-derived biomaterials, such as proteins and RNA. The close association of three proteins; endoplasmic reticulum (ER)-localized vesicle-associated membrane protein (VAMP)-associated protein VAP-A, oxysterol-binding protein (OSBP)-related protein ORP3 and small GTPase Rab7 is essential for the entrance and/or maintenance of Rab7+ late endosomes into NEI and the nuclear transfer of EV-derived biocomponents (e.g., proteins and nucleic acids) that in turns may regulate the gene expression in host (or EV-targeted) cells (Santos et al., J. Biol. Chem. 2018).