Abstract

Developing Novel High-Throughput Organ-on-a-Chip Tissue Models for Drug Discovery and Unlocking Their Full Potential Using High-Content Imaging and Analysis

Silvia Bonilla García, Scientist, MIMETAS B.V.

In this presentation, scientific experts from MIMETAS and Molecular Devices will introduce the culture and interrogation of complex 3D tissues models in the OrganoPlate®, a unique 3D organ-on-a-chip platform, including models for gut-on-a-chip, angiogenesis and immuno-oncology. We will show examples of Organ-on-a-Chip tissues for use in disease modeling and drug safety testing and will present the new OrganoPlate® Graft, which allows vascularization of spheroids, organoids and PDX explants, and offers a powerful solution for the study of angiogenesis, an important focus for cancer therapeutics. These complex 3D tissue cultures can be interrogated in a high-throughput manner using powerful cellular imaging and analysis systems. We will show how Molecular Device’s ImageXpress imaging systems play a vital role in the development and analysis of 3D tissue models, such as those built on the OrganoPlate® platform, by enabling translatable assays and readouts for healthy and diseased human organ models as well as quantitative characterization of complex phenotypic effects.