Abstract

What Microfluidics Can Do For Liquid Biopsy: Enabling the Accessibility and Clinical Utility of Circulating Biomarkers

Lorena Dieguez, Staff Researcher, INL

Early dissemination of cancer is difficult to detect by traditional imaging and pathological methods. While the presence of cancer material in body fluids is well known, current techniques for the isolation, analysis and characterization of these biomarkers are not efficient enough to be fully applied in clinical routine. Microfluidics presents numerous advantages for the handling of biological samples, as it provides careful control of fluids in the microscale. When it comes to biomarkers enrichment, microfluidics has demonstrated superior sensitivity and enhanced recovery compared to traditional methods. In this talk, we present our most recent work for integrated isolation and analysis of multiple circulating biomarkers and their validation in clinical settings.