Abstract

Multi-Cancer Early Detection Based on a Classifier for Extracellular Vesicle Biomarkers

Jean Lewis, Director, Research, Biological Dynamics

Simultaneous detection of multiple, early-stage cancers was tested using extracellular vesicle (EV) bound  protein markers from plasma purified by an alternating current electrokinetic (ACE) microarray.  In a case-control study, this method detected 95.7% of pancreatic, 75.0% of ovarian, and 43.8% of bladder cancers at 99.5% specificity, all at stage I.  The initial results suggest that this liquid biopsy screen may have  great promise for early stage, multi-cancer screening.