Abstract

Moving Urine as a Liquid Biopsy into Clinical practice: Bridging the Gap

Stephanie Jordaens, Biomedical Scientist, University of Antwerp and Novosanis

Urine is a promising alternative liquid biopsy, harboring valuable biomarkers, for detecting and monitoring treatment of urological and other cancer types. In terms of analysis, the isolation of various urinary analytes (such as DNA/RNA, cfDNA/cfRNA, EVs, proteins) shows great potential due to the ease of sampling and high acceptability compared to blood and tissue. Initial results of urinary biomarkers are presented for the use in multi-omic applications in prostate, breast and cervical cancer research. Here, we introduce Colli-Pee® containing UASTM preservative (RUO), as a self- sampling device for the standardization of urine collection, handling and storage to potentially bridge towards clinical applications.