Abstract

Single Particle Analyses Toolbox: The Key to Unlocking the Heterogeneity of Extracellular Vesicles

Randy Carney, Assistant Professor, University of California-Davis

The heterogeneity in composition and structure of individual EVs strongly contributes to their varied functions with respect to therapeutics. Yet it remains a challenge to examine structure-function at the resolution of single vesicles. In this talk, I will introduce a suite of high throughput commercial and custom tools that probe the structure and composition of single EVs, with a focus on spectroscopic techniques. I will examine best practices and key advantages of each technique, and provide an outlook of what is needed still to advance their study.