Abstract

Development of Continuous Crystallisation for Particle Control

Thomas McGlone, Research Fellow, University of Strathclyde

Crystallisation is a key process for the purification and isolation of many high value compounds including pharmaceuticals. However crystallisation is poorly understood and often inadequately controlled leading to scale-up issues and product inconsistency. There is increasing interest in exploiting the advantages of continuous crystallisation in the manufacturing of pharmaceuticals to provide reproducible, precise control over key product attributes. This presentation will give an overview of work being carried out within the UK EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation (CMAC, www.cmac.ac.uk) to develop continuous crystallisation processes for control of purity, yield, polymorphic or crystal form, morphology and particle size distribution. Examples will include characterisation of reactor performance, process characteristics and the development of a continuous crystallisation process at laboratory scale in an oscillatory baffled reactor for a novel co-crystal.