Thursday, 14 November 201308:00 | Registration | | Equipment for Continuous Flow Chemistry |
| | 09:45 | | 10:30 | Coffee Break and Networking in Exhibition Hall | 11:00 | Continuous Manufacturing – Hardware and Application Processes Olaf Stange, Researcher, Bayer Technology Services, Singapore
Flow Chemistry on the basis of process intensification or continuous manufacturing, has become an important topic in the fields of chemical and pharmaceutical industry. The presentation will illustrate the development in hardware and application processes. | 11:30 | Development of Continuous Crystallisation for Particle Control Thomas McGlone, Research Fellow, University of Strathclyde, United Kingdom
There is increasing interest in exploiting the advantages of continuous crystallisation in the manufacturing of pharmaceuticals to provide reproducible, precise control over key product attributes. This presentation will highlight work being carried out within the UK EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation (CMAC, www.cmac.ac.uk<http://www.cmac.ac.uk>) to develop continuous crystallisation processes for control of purity, yield, crystal form, morphology and particle size. | 12:00 | Lunch Break and Networking in Exhibition Hall | 12:45 | Poster Viewing Session | | Microfluidics Technology |
| | 13:30 | Microfluidic Extraction of Metal Ions from a Complex Mineral Leach Solution Craig Priest, Deputy Director, University of South Australia, Australia
Stream-based microfluidic solvent extraction of metal ions from complex industrial-grade leach solutions will be discussed in the context of mineral processing. The influence of fine particles and surface active reagents are evaluated, along with the path towards commercial throughput. | 14:00 | Microfluidic Factories for Advanced Functional Materials Saif Khan, Associate Professor, Chemical and Biomolecular Engineering, National University of Singapore, Singapore
In this talk I will discuss the design and development of microfluidics-based flow processes for exquisitely controlled fabrication of nano- and micro-structured functional materials. | 14:30 | Coffee Break and Networking in the Exhibition Hall | 15:00 | Capturing Fast Organometallic Transformations in Microfluidics Devices Marc Garland, Principal Scientist II, Institute of Chemical and Engineering Sciences (ICES), Singapore
Many organometallic transformations are very fast at room temperatures. This talk explains the combined use of a microfluidics device, Raman mapping and BTEM analysis better understand these transformations. | 15:30 | Microfluidic Flow Cells for Process Optimization in Enzyme Assisted Synthesis Claudia Gärtner, CEO, microfluidic ChipShop GmbH, Germany
The use of enzyme or cell cultures for the synthesis of special chemicals is an interesting field, in particular since they offer unique features for the synthesis of chirale components. To optimize such processes special conditions needs to be ensured and methods for process control should be implemented. Microfluidic systems are challenging tools to set-up and optimize enzyme based processes. Respective microfluidic modules and application data will be presented. | 16:00 | End of Day One |
Friday, 15 November 2013 | Flow Chemistry in Research and Development |
| | 09:30 | Thermochemical, Photochemical and Electrochemical Synthesis Under Flow David Harrowven, Professor, University of Southampton, United Kingdom
The Southampton Flow Chemistry Team focuses its effort on ‘reagentless’ transformations – particularly reactions triggered by heat, light and electricity. Herein an overview of our work is presented including reaction optimization and discovery, mechanistic studies and applications in target synthesis. | 10:00 | Implementation of Flow Chemistry in Exploratory Drug Development Bryan Li, Associate Research Fellow, Pfizer Pharmaceutical Science, United States of America
The application of flow chemistry in early stage drug development of various programs will be discussed. A fit-for-purpose approach is taken to address reaction safety issues and mitigate scale up risks. | 10:30 | Coffee Break and Networking in the Exhibition Hall | 11:00 | Development of a Sustainable Phase Transfer Catalysed Continuous Process for a Pharmaceutical Intermediate Soo Khean Teoh, Team Leader, Scientist II, Institute of Chemical and Engineering Sciences (ICES), Singapore
Evaluation of the synergetic sustainability benefits of operating a phase transfer catalyzed process in a continuous flow system compared to a batch process at scale. | 11:30 | Continuous Flow Processing of RAFT Polymers Christian Hornung, Research Group Leader, CSIRO, Australia
We developed a series of continuous flow processes for the synthesis and subsequent on-processing of RAFT polymers, using tubular reactor systems. This process provides a facile alternative scale-up route to conventional batch polymerisation. | 12:00 | Lunch Break and Networking in Exhibition Hall | 13:00 | Poster Viewing Session | 13:30 | | Keynote Presentation Development of a Meso-scale Continuous Flow System for In-situ Formation of Organometallic Reagents Loretta Wong, Development Manager, Institute of Chemical and Engineering Sciences, Singapore
A flexible continuous flow meso-scale mini-plant with the capability to run reactions with organometallic reagents of industrial significance, particularly the Grignard reaction has been designed by multi-disciplinary team at ICES Kilo Lab. Continuous preparation of the Grignard reagent ensures greater process safety by minimising inventory of the hazardous material and also allows greater flexibility of the chemistry by allowing non-commercially available Grignard reagents to be used directly in the process. |
| 14:15 | Coffee, Networking and Close of Conference |
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