08:00 | Registration |
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Microfluidicist's Toolbox of Forces |
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09:00 | Advancing Microchip Acoustophoretic Cell Handling in Life Science Applications
Johan Nilsson, Associate Professor, Lund University, Sweden
Recent advances in microchip acoustophoresis will be outlined, demonstrating tumor cell extraction and strategies to concentration and enrichment of biological species.
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09:30 | Attraction and Repulsion – Magnetic Forces for Particle and Cell Handling
Nicole Pamme, Professor in Analytical Chemistry, Stockholm University, Sweden
Microfluidic devices are presented for the trapping, focussing and deflection of particles and cells based on magnetic attraction and repulsion forces. |
10:00 | Dielectrophoretic Manipulation of Cells for Biomedical Applications
Claus Duschl, Head, Fraunhofer Institute for Biomedical Engineering, Germany
High-frequency electromagnetic fields in microfluidic systems are utilised (i) for the production of hybrid cells through the fusion of defined cell pairs and, (ii) for the characterization of the mechanical properties of cells for diagnostic purposes. |
10:30 | Coffee Break & Networking in Exhibition Hall |
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Market Orientated Device Development |
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11:15 | Assay Miniaturization Based on Centrifugal Microfluidics
Roland Zengerle, Professor, University of Freiburg, Germany
Centrifugal microfluidics enables sequential combination of microfluidic unit operations such as reagent storage and release, extraction of certain molecular species from complex samples, metering, mixing, incubation, enrichment and/or amplification on a low-cost substrate. We demonstrate this by implementing various assays in molecular diagnostics. |
11:45 | Microelectronics Meets Microfluidics: Integrated Sensors in Microfluidic Devices
Holger Becker, Chief Scientific Officer, Microfluidic ChipShop GmbH, Germany
In addition to the well established optical detection methods, a recent development in lab-on-a-chip technology is the increased use of sensor technology for the detection of analytes in a microfluidic system. These sensors can range from relatively simple electrochemical sensors to electronically read-out microarrays or highly integrated nano-electrode sensors with on-chip signal processing capabilities. These sensors require innovative technological solutions for their integration into a microfluidic cartridge. We will present solutions for such integrated systems for the detection of biomarkers, proteins and nucleic acids for applications in rapid infectious disease identification or drug efficacy monitoring. |
12:15 |  Technology Spotlight:
Industrialization & Economics of Smart Consumables in Life Sciences & Diagnostics
Philip Perry, Manager, Sony DADC
Smart Consumables with microstructures / microfluidic features and functionalised surfaces are prerequisites for emerging applications in the Life Sciences and in-vitro Diagnostics (IVD) markets. The increasing complexity of such new products in those markets requires new manufacturing technologies. Sony DADC is now applying its excellence in customised mass manufacturing and its efficient processes to these highly sophisticated consumables in its new OEM business in a B2B format with leading, innovative companies in the biomedical field.
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12:30 | Lunch & Networking in Exhibition Hall |
13:30 | Poster Viewing Session |
14:15 | Lab-on-a-Chip Technology for Diagnostic Applications – From the Research Lab to Real Products
Jaap den Toonder, Chief Scientist, Philips Research Laboratories, Netherlands
We are entering a phase in which commercial companies are adapting lab-on-a-chip technologies to develop real products. In this lecture I will show examples of such products we are currently developing: a handheld biosensor for immunoassays that can be used for magnetic or optical detection of drugs of abuse (DOA) in saliva, or cardiac markers (e.g. troponin) in blood, and cell-diagnostics applications. I will talk about the principles, (dis)advantages, and critical aspects for commercialization. |
14:45 | Microfluidic Devices Market. Materials,Market and Trends
Frederic Breussin, Business Unit Manager, Yole Developpement, France
This paper provides data on the microfluidic device market, with a special focus on materials, manufacturing processes and production costs. |
15:15 |  Technology Spotlight:
Bonding Your Future
Ray Karam, President and CEO, Invenios
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15:30 | Coffee Break & Networking in Exhibition Hall |
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Nanotech on a Chip |
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16:00 | Nanopore Sensors for Next Generation DNA Sequencing
Joshua Edel, Professor, Imperial College London, United Kingdom
We report on the fabrication and characterization of a DNA nanopore detector with integrated tunnelling electrodes for use as a possible route to high throughput DNA sequencing. |
16:30 | Enhancing the Capture of DNAs into Nanochannels via Engineering Nanochannel Inlets
Sunggook Park, Associate Professor, Louisiana State University, United States of America
One challenge in operating the nanochannel device is the difficulty in threading DNA molecules from microfluidic networks into small nanochannels electrophoretically. In this presentation, strategies to overcome this challenge by engineering nanochannel inlet structures will be shown. |
17:00 |  | Keynote Presentation Labs-on-a-Chip for Medical Applications
Albert Van Den Berg, Professor, University Of Twente, Netherlands
The recent rapid developments in microfluidics technologies has enabled the realization of miniaturized laboratories. These Labs-on-a-Chip will play an important role in future medicine, both in point-of-care devices for drug or biomarker monitoring, as well as in early diagnostic devices. We developed a pre-filled ready-to-use capillary electrophoresis platform for measuring ions in blood. It is used to monitor lithium in finger-prick blood of manic-depressive patients, but can also be used for measuring calcium in blood for prevention of milk fever, or for measuring creatinine in blood or sodium in urine for early detection of ESRD. Another device was developed for analyzing male fertility by determining sperm concentration and motility in semen. It appears that the same device can be easily adapted to detect the presence of cells in milk, a good indicator for the presence of mastitis.For early detection of colon cancer, nanowire sensors for detection of hypermethylated DNA will be presented, showing label-free DNA detection. The small size of these nanowire sensors enables the integration of a complete lab in a pill, that may be used as a screwening tool for early diagnostics of intestinal cancer. |
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17:30 | Drinks Reception |
