08:00 | Registration |
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Fluxomics and Pathway Discovery |
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10:00 |  | Keynote Presentation Metabolomics and Fluxomics of Lipid Mediators in Activated Macrophages and Human Plasma
Edward Dennis, Professor/Director, University of California San Diego, United States of America
Application of lipidomic analysis to characterize cellular lipid signaling of Toll-like and purinergic receptors and their “synergy” in stimulated macrophages including analysis of eicosanoid fluxes and effects of supplementation with omega-3 fatty acids as models for inflammation and infection. |
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10:30 | Coffee Break & Networking in Exhibition Hall |
11:15 | Fluxolipidomics of Fatty Acid Oxygenated Metabolites
Michel Lagarde, Professor, University of Lyon, France
Oxygenated metabolites from PUFA are very diverse and important bioactive molecules. However, their own metabolism arrests their activity or may allow the emerging of other functions. Cell phenotypes really depend on the life span of the bioactive intermediates and the expression of enzymes responsible for transforming these intermediates. Examples can be given starting from the essential fatty acids in mammals, i.e. within the omega-3 and -6 families. |
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Clinical Applications of Metabolomics |
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11:45 | Systems Biology Investigation of Acetaminophen-Induced Hepatotoxicity using Integrated Transcriptomics and Metabolomics
Patricia Noppinger, Lead Scientific Affairs, Metanomics Health, Germany
The combination of transcriptomic and metabolic profiling technologies provided insight into the pathways associated with acetaminophen-induced hepatotoxicity suggesting that hepatocyte necrosis results from a lack of energy or impaired energy production by mitochondria. |
12:30 | Lunch & Networking in Exhibition Hall |
13:30 | Poster Viewing Session |
14:15 | Building Tools for Biological Interpretation of Metabolomics Data
Alla Karnovsky, Assistant Professor, University of Michigan Medical School, United States of America
Recent progress in metabolomics has created an opportunity to advance our understanding of human disease. It also posed a number of bioinformatics challenges associated with data analysis and interpretation. I will describe several tools aimed at addressing these issues. |
14:45 | Tafazzin-Catalyzed Phospholipid-Lysophospholipid Transacylations: Self-Organization in a System of 105 Chemical Reactions
Michael Schlame, Associate Professor of Anesthesiology & Cell Biology, NYU Langone Medical Center, United States of America
Tafazzin is a mitochondrial enzyme that transfers fatty acids non-specifically from phospholipids to lysophospholipids. Here we present a mathematical approach to this unique enzymatic mechanism and show experimentally how tafazzin can produce highly specific molecular patterns in cardiolipin. |
15:15 | Coffee Break & Networking in Exhibition Hall |
16:00 | Towards in Situ Metabolic Profiling Using ToF-SIMS
Seetharaman Vaidyanathan, Lecturer, University of Sheffield, United Kingdom
We are developing secondary ion mass spectrometry imaging for in situ spatial metabolic profiling to capture contextual intra- and inter-cellular spatio-temporal metabolite localisations. The challenges of the current methodologies and its potential developmental scope will be discussed, in the context of other techniques currently available, including to our recent efforts at developing the technique. |
16:30 | Lipidomics as a Tool of Studying the Role of Membranes in the Heat Stress Management
Laszlo Vigh, Research Professor, Member of the Hungarian Academy of Sciences, Hungarian Academy Of Sciences, Hungary
Modulations in membrane fluidity and/or microheterogeneity achieved either by mild, fever-type heat stress or membrane fluidizing agents result in highly specific alterations in membrane lipid composition and can contribute to the production of lipid mediators controlling the expression of stress protein molecular chaperones. |
17:00 | Drinks Reception |
