David Hay,
Chair of Tissue Engineering, MRC Centre for Regenerative Medicine,
University of Edinburgh
David is the Professor of Tissue Engineering at the University of Edinburgh. Dave has worked in the field of stem cell biology and differentiation for over fifteen years. He and his team have highlighted the important role that pluripotent stem cells have to play in modelling human liver biology ‘in the dish’ and supporting failing liver function in vivo. The impact of this work has led to a number of peer-reviewed publications (>100), regular appearances at high profile conferences, and three start-up companies.
Generating Human Liver Spheres From Pluripotent Stem Cells and Their Application
Thursday, 13 June 2019 at 09:00
Add to Calendar ▼2019-06-13 09:00:002019-06-13 10:00:00Europe/LondonGenerating Human Liver Spheres From Pluripotent Stem Cells and Their Application3D-Culture, Organoids and Tox Screening Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Liver disease is an escalating global health issue. While liver transplantation is an effective mode of therapy, there are a shortage of donor organs. Therefore, developing renewable sources of human liver tissue is important for the clinic. Pluripotent stem cell-derived liver tissue represents a potential alternative to cadaver derived hepatocytes and whole organ transplant. At present, two-dimensional differentiation procedures deliver tissue that is hepatocyte like, but lacks certain functions and long-term stability. Efforts to overcome these limiting factors have focussed on building three-dimensional (3D) cellular aggregates. Although enabling for the field, their widespread application has been limited due to cost and overreliance on undefined biological components. Our studies focused on the development of self assembled 3D liver tissue under defined conditions. In vitro generated 3D tissues exhibited stable phenotype, providing an attractive resource for the clinic and long-term in vitro modelling studies. Our most recent tissue engineering advances will be discussed at the meeting.
Add to Calendar ▼2019-06-13 00:00:002019-06-14 00:00:00Europe/London3D-Culture, Organoids and Tox Screening Europe 20193D-Culture, Organoids and Tox Screening Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2019-06-13 09:00:002019-06-13 10:00:00Europe/LondonGenerating Human Liver Spheres From Pluripotent Stem Cells and Their Application3D-Culture, Organoids and Tox Screening Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
