Robert Halliwell,
Professor of Neuroscience and Clinical Pharmacology,
University of The Pacific
Robert F. Halliwell is Professor of Neuroscience and Clinical Pharmacology in the Schools of Pharmacy and Dentistry, University of the Pacific; he previously held a lectureship in Neuroscience at the University of Durham, England and a Research Fellowship at the University of California, Irvine. Dr Halliwell undertook graduate training at University College London and at Ninewells Hospital and Medical School, University of Dundee. His lab is conducting experiments to determine the functional properties of neurons derived from human stem cells; he has also published work in the history of medicine with a book on the history of the drug receptor concept.
Exploiting Human Stem Cells to Assess Risk of Developmental Neurotoxicity from Psychotropic Drugs
Friday, 14 June 2019 at 11:30
Add to Calendar ▼2019-06-14 11:30:002019-06-14 12:30:00Europe/LondonExploiting Human Stem Cells to Assess Risk of Developmental Neurotoxicity from Psychotropic Drugs3D-Culture, Organoids and Tox Screening Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
The developing human nervous system is highly susceptible to damage from environmental agents including heavy metals, organophosphate pesticides and pharmaceutical agents including psychotropic drugs. Determining the risk of neurotoxicity in humans using animal models is not very reliable. Our lab has been pioneering the study of human stem cells as a model of neurogenesis to address development neurotoxicity from psychotropic agents in vitro. This presentation will describe the experiments we are conducting investigating a variety of human stem cells, including tissue (adult) and induced pluripotent stem (iPS) cells to derive functional neurons. I will present the morphological, immunocytochemical, electrophysiological and neuropharmacological properties of neurons derived from human stem cells. I will also describe the impact of a range of psychotropic agents, including a number of antiepileptic medicines on the differentiation and maturation of human stem cells into functional neurons in vitro. Finally, I will present data on the value of human stem cell-derived neurons in the study of neuroprotection.
Add to Calendar ▼2019-06-13 00:00:002019-06-14 00:00:00Europe/London3D-Culture, Organoids and Tox Screening Europe 20193D-Culture, Organoids and Tox Screening Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2019-06-14 11:30:002019-06-14 12:30:00Europe/LondonExploiting Human Stem Cells to Assess Risk of Developmental Neurotoxicity from Psychotropic Drugs3D-Culture, Organoids and Tox Screening Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
