Steven C. George,
Edward Teller Distinguished Professor and Chair, Department of Biomedical Engineering,
University of California-Davis
Steven C. George, M.D., Ph.D. is a Professor of Biomedical Engineering at the University of California, Davis. He received his bachelors degree in chemical engineering in 1987 from Northwestern University, M.D. from the University of Missouri School of Medicine in 1991, and Ph.D. from the University of Washington in chemical engineering in 1995. He was on the faculty at the University of California, Irvine for 19 years (1995-2014) where he pursued a range of research interests including pulmonary gas exchange, lung mechanics, vascularizing engineered tissues, and microphysiological systems. The NIH FIRST award in 1998 and the CAREER and Presidential Early Career Award for Scientists and Engineers (PECASE) from the National Science Foundation in 1999 have previously recognized his work. While at UCI, he served as the William J. Link Professor and founding Chair of the Department of Biomedical Engineering (2002-2009), the Director of the Edwards Lifesciences Center for Advanced Cardiovascular Technology (2009-2014), and was the PI on a T32 predoctoral training grant from the National Heart Lung and Blood Institute. In 2014 he transitioned to become the Elvera and William Stuckenberg Professor and Chair of Biomedical Engineering at Washington University in St. Louis, and in 2017 moved to the UC Davis. He was elected a fellow in the American Institute of Medical and Biological Engineering (AIMBE) in 2007, a fellow of the Biomedical Engineering Society in 2017, has published more than 140 peer-reviewed manuscripts, and co-founded two early start-up companies. His work is currently funded by grants from the NIH that focus on creating tissue engineered models of the cardiac, pancreas, bone marrow, and cancer microenvironments using induced pluripotent stem cell and microfabrication technology.
“Bone Marrow-on-a-Chip”: A Strategy to Replicate Hematopoiesis and Cancer Cell Dormancy
Monday, 14 October 2019 at 11:30
Add to Calendar ▼2019-10-14 11:30:002019-10-14 12:30:00Europe/London“Bone Marrow-on-a-Chip”: A Strategy to Replicate Hematopoiesis and Cancer Cell Dormancy3D-Printing in the Life Sciences in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Tissue engineering holds enormous potential to not only replace or
restore function to a wide range of tissues, but also to capture and
control 3D physiology in vitro (e.g., microphysiological systems or
“organ-on-a-chip” technology). The latter has important applications in
the fields of drug development, toxicity screening, modeling tumor
metastasis, and repairing damaged cardiac (heart) muscle. In order to
replicate the complex 3D arrangement of cells and extracellular matrix
(ECM), new human microphysiological systems must be developed. The past
decade has brought tremendous advances in our understanding of stem
cell technology and microfabrication producing a rich environment to
create an array of “organ-on-a-chip” designs. Over the past six years
we have developed novel microfluidic-based systems of 3D human
microtissues (~ 1 mm3) that contain features such as perfused
human microvessels, primary human cancer, mouse tumor organoids, stem
cells, and spatiotemporal control of oxygen. The technologies are part
of two early start-up companies, Kino Biosciences and Immunovalent
Therapeutics, based in Irvine, CA and St. Louis, MO. This seminar will
describe our approach and early results on a strategy to create a 3D in
vitro model of human bone marrow with applications in hematopoiesis and
cancer cell dormancy.
Add to Calendar ▼2019-10-14 00:00:002019-10-15 00:00:00Europe/London3D-Printing in the Life Sciences3D-Printing in the Life Sciences in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com