| Conferences \ European Lab Automation \ Advances in Protein Crystallography \ Agenda \ Gerhard Klebe |
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From Fragments and Hot-Spots to Novel Lead StructuresThursday, 30 June 2011 at 09:30  Add to Calendar ▼2011-06-30 09:30:002011-06-30 10:30:00Europe/LondonFrom Fragments and Hot-Spots to Novel Lead Structures SELECTBIOenquiries@selectbiosciences.comGeneral experience shows that small molecule fragments, thought as initial leads for a drug design project, assemble in an ordered fashion in protein binding sites. Usually they populate at the hot spots of binding in protein surface-exposed binding pockets. Therefore, their crystallographic characterization is usually successful and the obtained structures provide a valid starting point for a subsequent optimization by growing the initially discovered fragments in the binding pocket via the decoration with suitable side chains. |
Add to Calendar ▼2011-06-30 00:00:002011-07-01 00:00:00Europe/LondonAdvances in Protein CrystallographySELECTBIOenquiries@selectbiosciences.com
