Jaydee Cabral's Biography

Jaydee Cabral, Research Fellow, Department of Chemistry, University of Otago

Jaydee Cabral is a Research Fellow in the Chemistry Department at the University of Otago where she has contributed greatly to the development, characterization, antimicrobial capacity, and biocompatibility of a commercialized chitosan/dextran-based surgical hydrogel, Chitogel™. Her current research involves sustained release of bioactives from nanoparticle hydrogel systems and the development of biomaterials as cell delivery vehicles for regenerative wound healing applications. She studied Chemistry at the College of William and Mary and received a PhD in Biomedical Sciences from Eastern Virginia Medical School. She then taught as a Lecturer at California State University prior to moving to the University of Otago in Dunedin, New Zealand.

In vitro Adipogenic and Osteogenic Differentiation of Bone-Marrow Derived Mesenchymal Stem Cells Using a Chitosan/Dextran-based Hydrogel

Friday, 17 March 2017 at 16:00

Add to Calendar ▼2017-03-17 16:00:002017-03-17 17:00:00Europe/LondonIn vitro Adipogenic and Osteogenic Differentiation of Bone-Marrow Derived Mesenchymal Stem Cells Using a Chitosan/Dextran-based HydrogelSELECTBIOenquiries@selectbiosciences.com

A chitosan/dextran-based (CD) injectable, nontoxic, surgical hydrogel has been developed and shown to be an effective post-operative aid in prevention of scar tissue formation in vivo. CD hydrogel’s effectiveness in a surgical setting prompted an investigation into its capacity as a potential bone marrow derived mesenchymal stem cell (BM-MSC) delivery vehicle for regenerative wound healing applications. By housing BM-MSCs within a biocompatible hydrogel matrix, viability and protection in cultivation, as well as direct delivery to the damaged site in the host tissue may be achieved. BM-MSC growth and proliferation in the presence of CD hydrogel were determined by Calcein-AM/Ethidium homodimer-1 fluorescence staining; and by nuclear staining with Hoechst 33342, followed by automated counting of micrographs using ImageJ. Flow cytometry studies revealed expression of a conventional BM-MSC surface marker profile. In addition, BM-MSCs in the CD hydrogel were able to successfully differentiate into adipocytes and osteocytes. In summary, the CD hydrogel supports MSC growth and differentiation; and therefore, may be used as a potential stem cell delivery vehicle for regenerative medicine and tissue engineering applications.

Add to Calendar ▼2017-03-16 00:00:002017-03-17 00:00:00Europe/LondonBioMEMS, Microfluidics and Biofabrication: Technologies and ApplicationsSELECTBIOenquiries@selectbiosciences.com

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