Sehyun Shin,
Professor & Director, Nano-Biofluignostic Engineering Research Center,
Korea University and Anam/Guro Hospital of Korea University
Professor Shin is currently professor of School of Mechanical Engineering and College of Medicine at Korea University and the director of Nano-Biofluignostic Engineering Research Center. He also has served as the Editor of the Journal of Mechanical Science and Technology (JMST). His research interests include the liquid biopsy for cancer and infectious viruses and the development of microfluidic technologies for disease detection, diagnosis and therapy. He has authored more than 150 peer-reviewed papers and delivered more than 130 invited talks and plenary lectures. He is as the president of International Society of Clinical Hemorheology as well as president of Biomedical Engineering Society of Cardiovascular Diseases. Prof. Shin co-founded three startups which are commercializing technologies developed in his lab. He has garnered many research awards and honors including Presidential citation of Science and Technology Merit by the Korean government, award for the Scientist of the month by NRF, the Academic award of KSME, the Nam-Heon Academic Award for Thermal engineering, Fellow of the ISCH, Fellow of KSME and Fellow of KSOR. Finally, Prof. Shin currently heads a group of 15 researchers.
Integrated Platelet Assays on a Microfluidic Platform
Thursday, 16 March 2017 at 17:00
Add to Calendar ▼2017-03-16 17:00:002017-03-16 18:00:00Europe/LondonIntegrated Platelet Assays on a Microfluidic PlatformSELECTBIOenquiries@selectbiosciences.com
Aggregation and adhesion of platelets to the vascular wall are consequences of platelet activation and these cascade processes play critical roles in hemostasis and thrombosis at vascular injury sites. In this study, we designed a simple and rapid assay of platelet aggregation and adhesion in a microfluidic system. To activate platelets, either shear stress or agonists was selectively chosen for the required test. For shear-induced platelet activation (SIPA), a rotating stirrer in a circular chamber was designed with considering shear generation with secondary-flow-induced mixing. Agonists such ADP, epinephrine and arachidonic acid were carefully combined with collagen or fibrinogen. When platelets were activated in whole blood, they were driven through the microchannel under vacuum pressure. Activated platelets adhered to a collagen or fibrinogen-coated surfaces on microchannel, causing blood flow to significantly slow and eventually stop. In order to conduct the above whole test with quick and easy operation, a microfluidic chip was carefully designed with mimicking in vivo environment. To measure platelet adhesion and aggregation, the migration distance (MD) of blood through the microchannel was monitored. As degree of platelet activation increased, MD gradually decreased. For platelet-excluded blood samples, the blood flow did not stop even at the end of microchannel. These findings imply that either SIPA or agonist-induced platelet activation can be examined with the present proposed microfluidic system. Also, the MD is a potentially valuable index for measuring the degree of platelet activation and aggregation. The proposed microfluidic system can examine various anti-platelet drug tests with rapidity and simplicity, which is of potential to be used at any point-of-care.
Add to Calendar ▼2017-03-16 00:00:002017-03-17 00:00:00Europe/LondonBioMEMS, Microfluidics and Biofabrication: Technologies and ApplicationsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2017-03-16 17:00:002017-03-16 18:00:00Europe/LondonIntegrated Platelet Assays on a Microfluidic PlatformSELECTBIOenquiries@selectbiosciences.com
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