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SELECTBIO Conferences 3D-Bioprinting, Tissue Engineering and Synthetic Biology

Pranav Soman's Biography



Pranav Soman, Professor, Biomedical and Chemical Engineering; IPA Program Director, Advanced Manufacturing (AM), National Science Foundation (NSF), Syracuse University

Pranav Soman holds two positions, as a Professor at Syracuse University, and as an IPA Rotator Program Director of the Advanced Manufacturing (AM) program at the National Science Foundation (NSF). As an academician, Prof. Soman’s central research focus is to develop new processing and printing technologies to create reliable models to capture key aspects of in vivo physiology and pathophysiology. Toward this goal, his group has developed a technology toolbox to provide a manufacturing solution to advance research in bioprinting, microfluidics, organ-on-chip, tissue engineering, regenerative medicine, and single cell analysis. He is also the founder of 3D Microfluidics LLC (3DM), a startup funded by NSF SBIR grant to provide cost-effective microfluidics solutions to researchers in life sciences. As a recently appointed Program Director at NSF, Prof. Soman’s roles include the advocacy of cutting-edge interdisciplinary research and education in advanced manufacturing and mentoring junior research members in the field.

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Perfusion Directed 3D-Bone Mineralization

Friday, 17 March 2017 at 15:00

Add to Calendar ▼2017-03-17 15:00:002017-03-17 16:00:00Europe/LondonPerfusion Directed 3D-Bone MineralizationSELECTBIOenquiries@selectbiosciences.com

An inherent challenge in conventional tissue engineering strategies is the ability to efficiently deliver nutrients throughout the thickness of a complex, physiologically relevant biomimetic construct. In lieu of adequate interstitial perfusion, cellular viability and physiological function is compromised. In this work, we will present the creation of structurally supported, perfusable hydrogels capable of growing bone in user defined directions. Briefly, bone-like human osteosarcoma cells were encapsulated inside UV cross-linkable gelatin methacrylate (GelMA) hydrogels, and this cell-hydrogel mixture was casted onto a 3D printed poly(vinyl alcohol) (PVA) structure. PVA serves as a sacrificial material and was dissolved away to obtain hollow channels to facilitate the perfusion of media using a custom-made acrylonitrile butadiene styrene (ABS) bioreactor. Osteogenic media was perfused through the channels, and the radial zones of bone mineralization surrounding the channels were quantified.  This study demonstrates that user-defined 3D printed channels can be used to spatially control bone mineralization.


Add to Calendar ▼2017-03-16 00:00:002017-03-17 00:00:00Europe/London3D-Bioprinting, Tissue Engineering and Synthetic BiologySELECTBIOenquiries@selectbiosciences.com