Bhushan Mahadik,
Assistant Director, NIH/NIBIB Center for Engineering Complex Tissues,
University of Maryland
Dr. Mahadik is the Assistant Director for CECT, and is at the University of Maryland. He received his Ph.D. in Chemical and Biomolecular Engineering under Prof. Harley from UIUC in 2014 and his B.S. in Chemical and Materials Science Engineering from the University of California, Berkeley in 2008. His research background spans tissue engineering techniques aimed at developing 3D biomaterial platforms to engineer the hematopoietic stem cell (HSC) niche, studying the effects of the bone marrow microenvironment on stem cell biology, and utilizing microfluidics-based and 3D printing biofabrication techniques to design patterned, hetergoeneous tissues. His research interests involve the use of Biomedical and Tissue Engineering approaches in translational science to develop clinically relevant therapies for patients.
3D Printing for Engineering Complex Tissues
Monday, 26 March 2018 at 10:30
Add to Calendar ▼2018-03-26 10:30:002018-03-26 11:30:00Europe/London3D Printing for Engineering Complex TissuesSELECTBIOenquiries@selectbiosciences.com
The generation of complex tissues has been an increasing focus in tissue
engineering and regenerative medicine. With recent advances in
bioprinting technology, our laboratory has focused on the development of
platforms for the treatment and understanding of clinically relevant
problems ranging from congenital heart disease to preeclampsia. We
utilize stereolithography-based and extrusion-based additive
manufacturing to generate patient-specific vascular grafts, prevascular
networks for bone tissue engineering, dermal dressings, cell-laden
models of preeclampsia, and bioreactors for expansion of stem cells.
Furthermore, we have developed a range of UV crosslinkable materials to
provide clinically relevant 3D printed biomaterials with tunable
mechanical properties. Such developments demonstrate the ability to
generate biocompatible materials and fabricated diverse structures from
natural and synthetic biomaterials. In addition, one of the key
challenges associated with the development of large tissues is providing
adequate nutrient and waste exchange. By combining printing and
dynamic culture strategies, we have developed new methods for generating
macrovasculature that will provide adequate nutrient exchange in large
engineered tissues. Finally, the use of stem cells in regenerative
medicine is limited by the challenge in obtaining sufficient cell
numbers while maintaining self-renewal capacity. Our efforts in
developing 3D-printed bioreactors that mimic the bone marrow niche
microenvironment have enabled successful expansion of mesenchymal stem
cells by recapitulating the physiological surface shear stresses
experienced by the cells. This presentation will cover the diverse
range of materials and processes developed in our laboratory and their
application to relevant, emerging problems in tissue engineering.
Add to Calendar ▼2018-03-26 00:00:002018-03-27 00:00:00Europe/LondonInnovations in Microfluidics, Biofabrication, Synthetic BiologySELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2018-03-26 10:30:002018-03-26 11:30:00Europe/London3D Printing for Engineering Complex TissuesSELECTBIOenquiries@selectbiosciences.com
