3D Chemical Compounds Screening Assay to Uncover Signalling Pathways Involved in CAFs-remodeling Tumor Microenvironment.Tuesday, 22 January 2013 at 14:15 Add to Calendar ▼2013-01-22 14:15:002013-01-22 15:15:00Europe/London3D Chemical Compounds Screening Assay to Uncover Signalling Pathways Involved in CAFs-remodeling Tumor Microenvironment. SELECTBIOenquiries@selectbiosciences.com Carcinoma Associated Fibroblasts (CAFs) can lead collective carcinoma cells invasion by extracellular matrix remodeling and tracks formation through actomyosin-dependent force generation. Using chemical compounds screening assay based on 3D matrix remodeling by CAFs, we identified Janus Kinase (JAK) signaling pathway as a regulator of actomyosin contractility and matrix remodeling by stroma cells. |