Extracellular Vesicle-Mediated Transfer of Functional RNA Between TissuesMonday, 21 March 2016 at 16:00 Add to Calendar ▼SELECTBIOenquiries@selectbiosciences.com Extracellular vesicles (EVs) emerge as important carriers for intercellular communication and they have been implicated in many biological processes. However, due to their small size and the difficulties of manipulating them, the data on EV biology has thus far been based mainly on in vitro or indirect in vivo evidence, or on experiments involving ex vivo manipulations. Furthermore, it is difficult to establish the exact cells of origin as well as individual cellular targets for in vivo experiments. Thus, the extent and pathogenic role of EV signalling in vivo, particularly with regard to the transfer of functional RNA, remains poorly understood. Using the Cre-Lox system we can overcome some of the major shortcomings in this field by establishing a method to trace the functional transfer of RNA by EVs in vivo. |