Roopali Gandhi's Biography

Roopali Gandhi, Assistant Professor in Neurology, Head of MS Biomarkers, Brigham and Women's Hospital/Harvard Medical School

Dr. Roopali Gandhi Assistant Professor in Neurology and Head of MS biomarkers at BWH. Dr. Gandhi helped in developing several novel projects for identifying a biomarker for Multiple Sclerosis (MS). During her research with circulating miRNAs, she identified several potential miRNAs, which are playing an important role in identifying MS disease staging and were linked to clinical parameters. She is now focused on major research that includes: (1) identification of immune biomarkers in MS, (2) study the novel molecular mechanism of immune cell regulation, and (3) understand the mechanism of action of therapies used for Multiple Sclerosis. She is member of neurology and immunology societies and an ad-hoc reviewer of neurology journals and grants.

Validation of miRNA as Diagnostic and Prognostic Biomarkers for Multiple Sclerosis

Monday, 20 March 2017 at 14:00

Add to Calendar ▼2017-03-20 14:00:002017-03-20 15:00:00Europe/LondonValidation of miRNA as Diagnostic and Prognostic Biomarkers for Multiple SclerosisSELECTBIOenquiries@selectbiosciences.com

Multiple sclerosis (MS) is an autoimmune disease characterized by progressive neuronal demyelination, resulting in varying degrees of disability over time. MS is usually diagnosed based on the clinical symptoms and Magnetic Resonance Imaging (MRI) analysis. There is an urgent need to find blood-based biomarker for MS disease diagnosis, disease stage, and to study treatment response. Following a two-year discovery and validation phase, we performed a multi-center international validation study aiming to investigate the potential use of miRNA expression as non-invasive biomarkers for MS disease diagnosis, disease stage, and association with MS clinical parameters. We found miRNAs that were differentially expressed in MS patients and associated with its clinical parameters. These miRNAs of interest exhibit clear biological significance in MS pathophysiology and are promising candidates for further exploration of their potential use in developing predictive diagnostic, prognostic, or therapeutic tools for MS.

Add to Calendar ▼2017-03-20 00:00:002017-03-21 00:00:00Europe/LondonCirculating Biomarkers: Cell-Free Nucleic Acids, Proteins and Rare Circulating CellsSELECTBIOenquiries@selectbiosciences.com

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