Erkki Ruoslahti,
Distinguished Professor and Former President,
Sanford Burnham Prebys Medical Discovery Institute
Dr. Erkki Ruoslahti is Distinguished Professor and former president of Sanford-Burnham Institute for Medical Research and a founder of the Center for Nanomedicine at University of California, Santa Barbara. Dr. Ruoslahti is a pioneer in the field of cell adhesion. His main discovery and invention is the integrin-binding tripeptide motif RGD and integrins that recognize this motif. He now studies specific vascular addresses in directing drugs to sites of disease. Dr. Ruoslahti’s is a member of the U.S. National Academy of Sciences and National Academy of Medicine. He is the recipient of a number of awards, including the Japan Prize and Gairdner Award, and Knight and Commander of the Orders of White Rose of Finland and Lion of Finland.
Disease-Specific Vascular Markers for Cancer, Atherosclerosis and Brain Diseases
Wednesday, 27 March 2019 at 09:30
Add to Calendar ▼2019-03-27 09:30:002019-03-27 10:30:00Europe/LondonDisease-Specific Vascular Markers for Cancer, Atherosclerosis and Brain DiseasesCirculating Biomarkers World Congress 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
We study peptides that home to specific targets in the body. We discover the homing peptides by screening phage libraries for peptides that direct homing of phages to the target tissue in vivo. The homing peptides, which usually bind to receptors in the vessels of the target tissue, can be used to selectively deliver diagnostic probes and drugs to the target. The latest development is the discovery of tumor-penetrating peptides. These peptides activate an endocytic bulk transport pathway we have dubbed the CendR pathway, which can enhance the exit from blood and tissue penetration co-administered compounds even without chemical coupling to the peptide (Ruoslahti, Adv Mater. (2012) 24 3747). We have also identified peptides specific for atherosclerotic plaques, accumulate at the site of a brain injury or recognize the blood vessels in Alzheimer’s disease brain. Our homing frequency have an intrinsic biological active I the disease they target. Examples of the peptide discovery process from initial screening to clinical trials will be given.
Add to Calendar ▼2019-03-27 00:00:002019-03-29 00:00:00Europe/LondonCirculating Biomarkers World Congress 2019Circulating Biomarkers World Congress 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2019-03-27 09:30:002019-03-27 10:30:00Europe/LondonDisease-Specific Vascular Markers for Cancer, Atherosclerosis and Brain DiseasesCirculating Biomarkers World Congress 2019 in Coronado Island, CaliforniaCoronado Island, CaliforniaSELECTBIOenquiries@selectbiosciences.com
