| Conferences \ Circulating Biomarkers World Congress 2016 \ Circulating DNA, Circulating RNA, Circulating Tumor Cells, Circulating Proteins \ Agenda \ Saumya Das |
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Mining for Functional Extracellular RNA Markers of Cardiac Remodeling: The Changing LandscapeTuesday, 22 March 2016 at 09:00  Add to Calendar ▼2016-03-22 09:00:002016-03-22 10:00:00Europe/LondonMining for Functional Extracellular RNA Markers of Cardiac Remodeling: The Changing LandscapeSELECTBIOenquiries@selectbiosciences.comExtracellular RNAs (ex-RNAs) have been exploited as biomarkers in many human diseases. We have described the discovery and validation of miRNA-30d as a plasma ex-RNA biomarker that correlates with cardiac remodeling in advanced heart failure, and that appears to play a functional role in cellular processes central to remodeling. In the new era of next-generation sequencing, investigators have attempted to use new discovery and validation platforms to identify novel ex-RNAs as biomarkers in diseases. In this talk, I will described the promise and pitfalls of RNA-sequencing, the challenge of validating RNA-sequencing, and our strategy of prioritizing biomarkers. I will discuss in detail the use of these strategies in the case of post-myocardial infarction remodeling. |
Add to Calendar ▼2016-03-21 00:00:002016-03-22 00:00:00Europe/LondonCirculating DNA, Circulating RNA, Circulating Tumor Cells, Circulating ProteinsSELECTBIOenquiries@selectbiosciences.com
