Saumya Das's Biography

Saumya Das, Assistant Professor in Medicine, Beth Israel Deaconess Medical Center and Mass General Hospital

Saumya Das M.D., Ph.D. is an Assistant Professor of Medicine at Beth Israel Deaconess Medical Center and Harvard Medical School and part of the Cardiovascular Institute. He is the lead PI of an NIH Common Fund Grant for studying extracellular RNAs as biomarkers in cardiovascular diseases, and his laboratory focuses on discovery of novel extracellular RNA biomarkers, understanding their role as mediators of intercellular communication, and developing therapeutic strategies using animal models.

Mining for Functional Extracellular RNA Markers of Cardiac Remodeling: The Changing Landscape

Tuesday, 22 March 2016 at 09:00

Add to Calendar ▼2016-03-22 09:00:002016-03-22 10:00:00Europe/LondonMining for Functional Extracellular RNA Markers of Cardiac Remodeling: The Changing LandscapeSELECTBIOenquiries@selectbiosciences.com

Extracellular RNAs (ex-RNAs) have been exploited as biomarkers in many human diseases. We have described the discovery and validation of miRNA-30d as a plasma ex-RNA biomarker that correlates with cardiac remodeling in advanced heart failure, and that appears to play a functional role in cellular processes central to remodeling. In the new era of next-generation sequencing, investigators have attempted to use new discovery and validation platforms to identify novel ex-RNAs as biomarkers in diseases. In this talk, I will described the promise and pitfalls of RNA-sequencing, the challenge of validating RNA-sequencing, and our strategy of prioritizing biomarkers. I will discuss in detail the use of these strategies in the case of post-myocardial infarction remodeling.

Add to Calendar ▼2016-03-21 00:00:002016-03-22 00:00:00Europe/LondonCirculating DNA, Circulating RNA, Circulating Tumor Cells, Circulating ProteinsSELECTBIOenquiries@selectbiosciences.com

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